Using cutting-edge technologies of synthetic biology, the emerging field of Synthetic Microbiome aims to engineer complex microbial communities to achieve desired function and stability. Rational design and precise modulation of microbial communities holds promise for solving important issues in multiple areas, including human health, sustainable agriculture, etc. The Center for Synthetic Microbiome will create an innovative ecosystem to promote basic research of synthetic microbial communities as well as their applications in medicine, agriculture and bio-manufacturing.