Center for Quantitative Synthetic BiologyCenter for Synthetic GenomicsCenter for Synthetic BiochemistryCenter for Synthetic MicrobiomeCenter for Genome Engineering and TherapyCenter for Synthetic ImmunologyMaterials Synthetic Biology Center(MSBC)Center for Cell and Gene Circuit DesignMedical CenterCenter for DNA Synthesis Key InstrumentAgricultural and Plant Synthetic Biology

Center for Quantitative Synthetic Biology

The Center has now brought together many outstanding young talents in the fields of quantitative biology and synthetic biology. Applying quantitative analysis into synthetic biosystem, the Center focuses on basic scientific problems such as tumor bacterial therapy and drug-resistant bacterial intervention, exploring major scientific problems such as the nature of life and the origin of life, and is actively committed to industrial cooperation and application exploration. The center team currently gathers many cross-complementary research groups including synthetic biology, microbiology, physics, bioinformatics, microfluid analysis chemistry, proteomics, and biomaterials.

    Center for Synthetic Genomics

    The development of genomics over the past decade has not only given us a comprehensive and in-depth understanding of the genetic material of various organisms, but also enabled us to open up a treasure trove of precious species and genes. Synthetic genomics was fortunately based on this. It aims to better understand the biological nature of the genome and to systematically analyze the biological functions of the entire genome by designing and reengineering the de novo synthesis method, and to give it new features. Research and application. At present, the center has formed an international research team composed of Jie Qing, Qing Qian, etc., from the Institute of Synthetic Biology, Institute of Advanced Biology, Chinese Academy of Sciences, Institute of synthetic biology, Dr. Dai Junchuang, and Dr. Cai Yizhi, the chief professor of Manchester Manst University. Jointly serving as director, the academician of the New York University School of Medicine Jeff Buka (confirmed Chinese name) serves as honorary director and aims to build a world-class research center for synthetic genomics. The main research directions of the center include: 1. Development of gene and gene combinations into use technology; 2. Genome design and analysis; 3. The application of synthetic biology.

    Center for Synthetic Biochemistry

    The Center for Synthetic Biochemistry is directed by Jay D. Keasling, an member of National Academy of Engineering.It has gathered many talents in the fields of biology and metabolic engineering. Based on synthetic biology, guided by market demand and regional strategy, the center is committed to the development of new synthetic biochemical theories and methods, and the use of cutting-edge synthetic biology technology to transform the natural metabolism that already exists in nature (plants, fungi, animals) Pathways, and the introduction of engineered microorganisms, based on cheap raw materials to prepare valuable natural or non-natural products.

      Center for Synthetic Microbiome

      Using cutting-edge technologies of synthetic biology, the emerging field of Synthetic Microbiome aims to engineer complex microbial communities to achieve desired function and stability. Rational design and precise modulation of microbial communities holds promise for solving important issues in multiple areas, including human health, sustainable agriculture, etc. The Center for Synthetic Microbiome will create an innovative ecosystem to promote basic research of synthetic microbial communities as well as their applications in medicine, agriculture and bio-manufacturing.

        Center for Genome Engineering and Therapy

        The mission of Center for Genome Engineering and Therapy (CGET) is developing the cutting-edge approaches to editing, writing and regulating nucleic acids (DNA and RNA) and proteins for human healthcare and therapeutics. The main research directions of the center include: (i)Genome engineering technology: Rewriting human Genome; (ii)Gene therapy and cell therapy: Aging reversal; (iii)Precision Medicine: Genomics and omics analysis for diagnosis.

          Center for Synthetic Immunology

          Synthetic immunology is an emerging discipline that is highly integrated with cutting-edge immunological theories and modern synthetic biology technology. This has greatly promoted the development of modern theories, technical approaches and product research of immunotherapy for major diseases. The Center for Synthetic Immunology has gathered pioneers and outstanding young talents in synthetic immunology with the aim to cure tumors, autoimmune diseases, viral diseases, organ transplant and other diseases. Our approach is to provide new opportunities to reshape, renormalize, or rebuild the immune system of the body through immunotherapy. The center aims at applying new synthetic immunology theories and approaches to achieve the immunotherapy of major diseases and large-scale industrial production for treatment. At present, the center team is recruiting research groups in many disciplines including immunology, synthetic biology, structural biology, multi-omics and bioinformatics, biomacromolecule drugs, cell-based therapeutics and tissue or organ engineering.

            Materials Synthetic Biology Center(MSBC)

            The rapid and concomitant development in frontier methods for the controlled synthesis and characterization of biomaterials at the molecular, nanoscale level, combined with the technological advances in reading and writing genomic, proteomic, metabolomic, and epigenetic information, provide a unique set of opportunities to bring together scientists and engineers from these traditionally disparate fields into a common community. Under such circumstances, Materials Synthetic Biology emerges as a new discipline that lies at the nexus of the physical sciences, life sciences, and engineering, where the tools and tactics of materials science and other engineering principles are used to interrogate, manipulate, and generate new function in biological systems, while at the same time the concepts and components of biology are employed to create new sustainable materials of fundamental interest and societal benefit. Residing in Shenzhen Institute of Synthetic Biology (iSynBio), the newly established Materials Synthetic Biology Center strives to build up an internationally renowned, first-class research hub, where technological innovation and education of the next generation scientists are intimately integrated, and cross-disciplinary collaborations are highly encouraged. The current key research areas of the center include: (1) "Living" functional materials; (2) Semiconductor synthetic biology; (3) Programmable biomaterials and applications in biomedicine, bioenergy and bioelectronics.

              Center for Cell and Gene Circuit Design

              Living system requires the fundamental capability to sense and process multiplex input signals, and make accurate cellular decisions. Inspired by the electronic engineering, these biological information processing systems are governed by various gene circuits, including signaling transduction, genetic regulation, metabolic and energetic regulation etc., which may function as the "Central Processor Unit" in synthetic living systems. The understanding of the design principle and regulatory mechanism of natural cell and gene circuits, can uncover the basic law of living system, but also establish the substantial theoretical and technological foundation for the intelligent, automatic control in the next generation of engineering biology. Aiming at the crucial scientific challenges and the cutting-edge biotechnology in synthetic lives, our center will focus on the development of "software" in the design of synthetic lives, to promote interdisciplinary biological science and education. In the next five years, our researches will focus on the following directions: 1) the modular design of key biological parts and devises; 2) the development of computational theories and software for the cell and gene circuits design; 3) the development of smart cell and gene therapeutics.

                Medical Center

                Focusing on key scientific questions about the development mechanism of major diseases and correspondingly translational applications, Shenzhen innovation institute of synthetic biology medical center use of synthetic biology technologies to develop innovative diagnosis, treatment methods and individualized treatment applications. The center has deployed three major research fields, which are basic medical research, synthetic enabling technology and translational medicine, and conducted extensive explorations in clinical applications as well. In order to take advantages of combining synthetic biology with medical research, the center has gathered multidisciplinary and complementary groups from synthetic biology, disease genomics, tumor biology, bioinformation, proteomics, metabolomics and so on, with more than 20 outstanding young Principal Investigators and over 200 researchers.

                  Center for DNA Synthesis Key Instrument

                  Comparing with genome sequencing, which facilitates the digitization of life, synthetic biology has enabled human beings to explore the nature of life and promote the cross-disciplinary applications in medicine, chemical industry, agriculture and IT technologies. Since DNA synthesis serves as the fundamental technology of synthetic biology, the center focus on resolving the bottleneck restrict of synthetic biology key technologies and its instrumental development. The center has attracted experienced talents with overseas and multidisciplinary backgrounds including Synthetic Biology, Chemistry, Molecular Biology, Mechanical Engineering, and Computer Science.

                    Agricultural and Plant Synthetic Biology

                    Center for Agricultural and Plant Synthetic Biology is committed to assembling and nurturing world-class synthetic biologists and engineering professionals, with a focus on crucial agricultural crops, economic plants, algae, agricultural microbes, and the prospective realms of green biological agriculture manufacturing. Applying synthetic biological principles and techniques, the center endeavors to innovate disruptive technologies and products in agricultural synthetic biology. It aims to establish next-generation automated and intelligent factories adept at nurturing genetically improved varieties of plants and algae. This is part of a broader objective to construct a comprehensive innovation ecosystem that encompasses a journey from fundamental research through applied investigation to the fruition of transformative achievements. This orchestrated endeavor is directed towards accelerating the development of innovative crop and algae lineages that epitomize heightened productivity, minimized consumption, superior quality, and enhanced value-added attributes. Such an initiative is instrumental in serving national priorities in food security and promoting the sustainable advancement of green agricultural practices.


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