Papers

Hu, Z.#, Yin, Z.#, Lu, G., Luo, Q., He, X., Zhan, L., Goldfuss, B., Xu, J.*, Bian, G.*, & Dickschat, J. S*. (2026). Systematic Discovery of Bacterial Diterpene Synthases and Structure-Guided Functional Interconversion of ShHS and CbCSJournal of the American Chemical Society, 10.1021/jacs.6c02649 . https://doi.org/10.1021/jacs.6c02649

Yin, Z.#, Hu, Z.#, He, X., Xu, J., Goldfuss, B.*, Dickschat, J. S.*, & Bian, G.* (2026). Strong Implications From Small Deviations in Labeling Patterns: The Mechanism of Burkholderia gladioli Pacifigorgiadiene SynthaseChemistry , e00029. https://doi.org/10.1002/chem.202600029

Yin, Z.#, Hu, Z.#, Yang, K., Lu, G., Tabekoueng, G. B., Wu, P., Luo, Q., Xu, J., Goldfuss, B., Dickschat, J. S.*, & Bian, G.* (2025). Biosynthesis of the Red Algal Diterpene Peyssonnosol in BacteriaAngewandte Chemie (International ed. in English)64(34), e202507752. https://doi.org/10.1002/anie.202507752

Zhang, X.#, Cheng, S., Yang, J., Lu, L., Deng, Z., Bian, G., & Liu, T. (2024). Metabolic engineering of Glarea lozoyensis for high-level production of pneumocandin B0Synthetic and systems biotechnology10(2), 381–390. https://doi.org/10.1016/j.synbio.2024.12.008

Wang, Q.#, Hu, Z.#, Li, Z.#, Liu, T.*, & Bian, G*. (2023). Exploring the Application and Prospects of Synthetic Biology in Engineered Living MaterialsAdvanced Materials 37(31), e2305828. https://doi.org/10.1002/adma.202305828

Tao, H.#, Lauterbach, L.#,Bian, G.#, Chen, R.#, Hou, A.#, Mori, T.#, Cheng, S., Hu, B., Lu, L., Mu, X., Li, M., Adachi, N., Kawasaki, M., Moriya, T., Senda, T., Wang, X., Deng, Z., Abe, I.*, Dickschat, J. S.*, & Liu, T.* (2022).Discovery of non-squalene triterpenes.Nature606(7913), 414–419. https://doi.org/10.1038/s41586-022-04773-3

Yuan, Y.#, Cheng, S.#,Bian, G.#, Yan, P., Ma, Z., Dai, W., Chen, R., Fu, S., Huang, H., Chi, H., Cai, Y., Deng, Z., Liu, T.* (2022),Efficient exploration of terpenoid biosynthetic gene cluster in filamentous fungi.Nature Catalysis, 5, 259–267.

Chen, R., Feng, T., Li, M., Zhang, X., He, J., Hu, B., Deng, Z., Liu, T., Liu, J. K.*, Wang, X.*, & Bian, G*. (2022).Characterization of Tremulane Sesquiterpene Synthase from the Basidiomycete Irpex lacteus.Organic letters24(31), 5669–5673. https://doi.org/10.1021/acs.orglett.2c01975

Chen, R., Jia, Q., Mu, X., Hu, B., Sun, X., Deng, Z., Chen, F.*,Bian, G.*, & Liu, T*. (2021).Systematic mining of fungal chimeric terpene synthases using an efficient precursor-providing yeast chassis. Proceedings of the National Academy of Sciences of the United States of America118(29), e2023247118. https://doi.org/10.1073/pnas.2023247118

Siemon, T.#, Wang, Z.#,Bian, G.#, Seitz, T., Ye, Z., Lu, Y., Cheng, S., Ding, Y., Huang, Y., Deng, Z., Liu, T., & Christmann, M. (2020).Semisynthesis of Plant-Derived Englerin A Enabled by Microbe Engineering of Guaia-6,10(14)-diene as Building Block. Journal of the American Chemical Society142(6), 2760–2765. https://doi.org/10.1021/jacs.9b12940

He, H.#,Bian, G.#, Herbst-Gervasoni, C. J., Mori, T., Shinsky, S. A., Hou, A., Mu, X., Huang, M., Cheng, S., Deng, Z., Christianson, D. W., Abe, I., & Liu, T. (2020).Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nature communications, 11(1), 3958. https://doi.org/10.1038/s41467-020-17642-2

Bian, G.#, Rinkel, J.#, Wang, Z., Lauterbach, L., Hou, A., Yuan, Y., Deng, Z., Liu, T., & Dickschat, J. S. (2018).A Clade II-D Fungal Chimeric Diterpene Synthase from Colletotrichum gloeosporioides Produces Dolasta-1(15),8-diene. Angewandte Chemie (International ed. in English), 57(48), 15887–15890. https://doi.org/10.1002/anie.201809954

Bian G, Ma T, Liu T. In Vivo Platforms for Terpenoid Overproduction and the Generation of Chemical Diversity. Methods Enzymol.2018;608:97-129. doi:10.1016/bs.mie.2018.04.025

Bian, G.#, Hou, A.#, Yuan, Y., Hu, B., Cheng, S., Ye, Z., Di, Y., Deng, Z., & Liu, T. (2018).Metabolic Engineering-Based Rapid Characterization of a Sesquiterpene Cyclase and the Skeletons of Fusariumdiene and Fusagramineol from Fusarium graminearum.Organic letters20(6), 1626–1629. https://doi.org/10.1021/acs.orglett.8b00366

Bian, G., Deng, Z., & Liu, T. (2017).Strategies for terpenoid overproduction and new terpenoid discovery. Current opinion in biotechnology, 48, 234–241. https://doi.org/10.1016/j.copbio.2017.07.002

Bian, G.#, Han, Y.#, Hou, A., Yuan, Y., Liu, X., Deng, Z., & Liu, T. (2017).Releasing the potential power of terpene synthases by a robust precursor supply platform. Metabolic engineering, 42, 1–8. https://doi.org/10.1016/j.ymben.2017.04.006

Bian, G.,Yuan, Y., Tao, H., Shi, X., Zhong, X., Han, Y., Fu, S., Fang, C., Deng, Z., & Liu, T. (2017).Production of taxadiene by engineering of mevalonate pathway in Escherichia coli and endophytic fungus Alternaria alternata TPF6Biotechnology journal12(4), 10.1002/biot.201600697. https://doi.org/10.1002/biot.201600697