Synthetic Epigenetic

Views:810       Publish Time: 2019-07-04

In the last decades, the research in the field of epigenetics were focused mostly on mapping various epigenomic modifications at a global scale in different cell types from healthy and diseased tissues and organisms and to correlate them with gene expression. Even though tremendous amount of information has been collected, we are still far from the complete understanding of epigenetic processes, especially concerning the cause and consequence of chromatin marks with respect to gene expression and other regulatory processes. We will develop forward-engineering approaches directly interrogate the relationships between the epigenome and transcriptional function. It will provide opportunities to transform the increasingly precise genome-wide maps for developmental and disease states into therapeutics and other benefits for human health.