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# co-first author *Corresponding authors
Qing Wen#, Jiaqi Zhou#, Congcong Tian#, Xinran Li#, Guibing Song#,Yuan Gao,
Yaping Sun, Chiyuan Ma, Sitong Yao,
Xiaoyan Liang, Xing Kang, Nan Wang, Yuan
Yao, Hongbao Wang, Xiaohuan Liang, Jialin
Tang, Steven M. Offer, Xiaohua Lei, Chuanhe
Yu, Xiangyu Liu, Zichuan Liu, Zhiquan
Wang, and Haiyun Gan*, ‘Symmetric inheritance of parental histones contributes to safeguarding the fate of mouse embryonic stem cells during differentiation’ Nature Genetics ,（2023）
Congcong Tian#, Jiaqi Zhou#, Xinran Li#, Yuan Gao, Qing Wen, Xing Kang, Nan Wang, Yuan Yao, Jiuhang Jiang, Guibing Song, Tianjun Zhang, Suili Hu, JingYi Liao, Chuanhe Yu, Zhiquan Wang, Xiangyu Liu, Xin-hai Pei, Kuiming Chan, Zichuan Liu & Haiyun Gan*. "Impaired histone inheritance promotes tumor progression" Nature Communications , (2023)
Yao Y#, Wen Q#, Zhang T, Yu C, Chan KM, Gan H*. "Advances in Approaches to Study Chromatin-Mediated Epigenetic Memory". ACS Synth Biol. doi: 10.1021/acssynbio.1c00394. (2021)
Albert Serra-Cardona, Chuanhe Yue , Xinmin Zhang , Xu Hua, Yuan Yao , Jiaqi Zhou , Haiyun Gan*, and Zhiguo Zhang*, "A mechanism for Rad53 to couple leading- and lagging-strand DNA synthesis under replication stress in budding yeast." PNAS, 118: e2109334118. (2021)
Xinran Li#,Jiaqi Zhou#, Wenjuan Zhao#, Qing Wen#, Weijie Wang, Huipai Peng, Yuan Gao, Kelly J. Bouchonville, Steven M. Offer, Kuiming Chan, Zhiquan Wang*, Nan Li*, Haiyun Gan*."Defining proximity proteomics of histone modifications by antibody-mediated protein A-APEX2 labeling"Genomics, Proteomics & Bioinformatics, (2021)
Q. Wen#, Y. Yao#, X. Li, Z. Hu, H. Mei, H. Gan*. "Chromatin replication and parental histone allocation. "Genome Instability & Disease. 2:51–58 (2021)
Yu, C#, H. Gan#, A. Serra-Cardona, L. Zhang, S. Gan, S. Sharma, E. Johansson, A. Chabes, R. M. Xu and Z. Zhang. "A mechanism for preventing asymmetric histone segregation onto replicating DNA strands". Science 361, 1386-1389 (2018). (Highlighted in Science and F1000)
Li, S., Z. Xu, J. Xu, L. Zuo, C. Yu, P. Zheng, H. Gan, X. Wang, L. Li and S. Sharma. "Rtt105 functions as a chaperone for replication protein A to preserve genome stability." The EMBO journal: e99154 (2018).
H. Gan#, A. Serra-Cardona#, X. Hua, H. Zhou, K. Labib, C. Yu and Z. Zhang. The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands. Mol Cell 72(1): 140-151 e143 (2018).
Fang, D#, H. Gan#, L. Cheng, J. H. Lee, H. Zhou, J. N. Sarkaria, D. J. Daniels and Z. Zhang. H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. ELife, 7 (2018).
H. Gan#, C. Yu#, S. Devbhandari, S. Sharma, J. Han, A. Chabes, D. Remus and Z. Zhang*, Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress. Mol Cell 68, 446-455 e443 (2017). (Highlighted in Cell Cycle)
Zhang, H#, H. Gan#, Z. Wang#, J. H. Lee, H. Zhou, T. Ordog, M. S. Wold, M. Ljungman and Z. Zhang*. RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells. Mol Cell, 65(2):272-284 (2017). (Highlighted in F1000)
Fang, D#, H. Gan#, J. H. Lee#, J. Han#, Z. Wang#, S. M. Riester, L. Jin, J. Chen, H.Zhou, J. Wang, H. Zhang, N. Yang, E. W. Bradley, T. H. Ho, B. P. Rubin, J. A. Bridge, S. N. Thibodeau, T. Ordog, Y. Chen, A. J. van Wijnen, A. M. Oliveira, R. M. Xu, J. J.Westendorf and Z. Zhang*, The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas. Science 352, 1344-1348 (2016). (Highlighted in F1000)
C. Yu#, H. Gan# and Z. Zhang*.Both DNA Polymerases delta and Contact Active and Stalled Replication Forks differently. Mol Cell Biol, 37(21) (2017).
Feng, J#, H. Gan#, M. L. Eaton, H. Zhou, S. Li, J. A. Belsky, D. M. MacAlpine, Z. Zhang* and Q. Li*, Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells. Mol Cell Biol 36, 1856-1867 (2016).
C. Yu#, H. Gan#, J. Han, Z. X. Zhou, S. Jia, A. Chabes, G. Farrugia, T. Ordog, Z. Zhang*. Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall. Mol Cell, 56, 551-563 (2014). (Highlighted in Molecular Cell and F1000)
H. Gan#, L. Wen#, S. Liao#, X. Lin, T. Ma, J. Liu, C. X. Song, M. Wang, C. He*, C. Han*, F. Tang*. Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis. Nat Commun 4, 1995 (2013).
H. Gan#, T. Cai#, X. Lin, Y. Wu, X. Wang, F. Yang*, C. Han*. Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis. Mol Cell Proteomics, 12, 1144-1157 (2013).
H. Gan, X. Lin, Z. Zhang, W. Zhang, S. Liao, L. Wang, C. Han*. piRNA profiling during specific stages of mouse spermatogenesis. RNA, 17, 1191-1203 (2011).
Hashizume, R., N. Andor, Y. Ihara, R. Lerner, H. Gan, X. Chen, D. Fang, X. Huang, M. W. Tom and V. Ngo. "Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma." Nature medicine 20(12): 1394 (2014).
Chen, X., M. Zhang, H. Gan, H. Wang, J.-H. Lee, D. Fang, G. J. Kitange, L. He, Z. Hu and I. F. Parney. "A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma." Nature communications 9(1): 2949 (2018).
Gao, Y., H. Gan, Z. Lou and Z. Zhang. "Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation." PNAS115(27): E6162-E6171. (2018).
Li, S., Z. Xu, J. Xu, L. Zuo, C. Yu, P. Zheng, H. Gan, X. Wang, L. Li and S. Sharma. "Rtt105 functions as a chaperone for replication protein A to preserve genome stability." The EMBO journal: e99154 (2018).
Wu, R., Z. Wang, H. Zhang, H. Gan and Z. Zhang. "H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication." Nucleic acids research 45(1): 169-180. (2016).
Chan, K. M., J. Han, D. Fang, H. Gan and Z. Zhang. "A lesson learned from the H3. 3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?" Cell cycle 12(16): 2546-2552 (2013).
Fang, D., H. Gan, H. Wang, H. Zhou and Z. Zhang. "Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells." Cell Cycle 16(19): 1781-1789 (2017).
Hou, X., W. Zhang, Z. Xiao, H. Gan, X. Lin, S. Liao and C. Han. "Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis." BMC genomics 13(1): 495. (2012).
Yang, Y., Y. Feng, X. Feng, S. Liao, X. Wang, H. Gan, L. Wang, X. Lin and C. Han. "BMP4 cooperates with retinoic acid to induce the expression of differentiation markers in cultured mouse spermatogonia." Stem cells international. (2016).
Yang, Y., M. Leonand and H. Gan. "Viral and Nonviral Cancer Gene Therapy. THE WORLD SCIENTIFIC ENCYCLOPEDIA OF NANOMEDICINE AND BIOENGINEERING I: Volume 3: Nanotechnology in Gene Delivery", World Scientific: 1-52. (2017).
Yu, C., H. Gan and Z. Zhang. "Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast. Genome Instability, Springer: 227-238. (2018).
L Cheng, X Zhang, Y Wang, H Gan, X Xu, X Lv, X Hua, J Que, T Ordog. "Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit. " Nucleic acids research 47 (21), 11114-11131. (2019)
JS Lee, Y Mo, H Gan, RJ Burgess, DJ Baker, JM van Deursen, Z Zhang. "Pak2 kinase promotes cellular senescence and organismal aging. " Proceedings of the National Academy of Sciences 116 (27), 13311-13319. (2019)
SW Yang, L Li, JP Connelly, SN Porter, K Kodali, H Gan, JM Park . "A cancer-specific ubiquitin ligase drives mRNA alternative polyadenylation by ubiquitinating the mRNA 3′ end processing complex. " Molecular Cell 77 (6), 1206-1221. e7. （2020）
Chan, K. M., J. Han, D. Fang, H. Gan and Z. Zhang. "A lesson learned from the H3. 3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?" Cell cycle 12(16): 2546-2552. (2013)
