1. Metabolic rewiring for synthetic metabolism

Views:1513       Publish Time: 2017-11-09

The main challenge to overcome when establishing bio-based processes is to develop cell factories that can produce chemicals at costs that are competitive with fossil-based fuels and chemicals. In order to generate economically feasible bio-based processes, cell factories must be developed around three key performance parameters: titer, rate (productivity), and yield (TRY). Strains can be developed through metabolic rewiring, which is the metabolic reconfiguration in a cell where redox status, bioenergetics and central carbon flux are reprogrammed to support cell proliferation and production of a new chemical. 

1. 细胞工厂构建 

以催化性能为指标，构建微生物细胞工厂将葡萄糖或其他碳源高效转化为高附加值的化学品。 

2. 工艺开发

围绕细胞工厂的商业化应用，开发与之相匹配的发酵放大与产物提取工艺。