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# co-first author *Corresponding authors
Lu X#, Chang M#, Li X#, Cao W, Zhuang Z, Wu Q, Yu T*, Yu A*
and Tang H*. Metabolic engineering for sustainable xylitol production from diverse carbon sources in Pichia pastoris. Microbial Cell Factories, 2025, 24: 59.
Chen K#, Maimaitirexiati G#, Zhang Q, Li Y, Liu X, Tang H, Gao X, Wang B*, Yu T*, Guo S*. CRISPR-Cas9-based one-step multiplexed genome editing through optimizing guide RNA processing strategies in Pichia pastoris. Synthetic and Systems Biotechnology, 2025, 10: 484-494.
Sun D, Wu L, Lu X, Li C, Xu L, Li H, He D, Yu A, Yu T, Zhao J, Tang H, Bao X. Engineering transcriptional regulatory networks for improving second-generation fuel ethanol production in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2024, 10(1): 207-217.
Zhuang Z#, Wan G#, Lu X, Xie L, Yu T* and Tang H*. Metabolic engineering for single-cell protein production from renewable feedstocks and its applications. Advanced Biotechnology, 2024, 2:35.
Bai Z, Guo S, Yang Y, Zhuang Z, Cao W, Yang Y, Yu T, Tang H. Microbial production of food compounds with carbon dioxide and derived low-carbon molecules as substrates. Chinese Journal of Biotechnology, 2024, 40(8):2731-2746.
Zeng T, Jin Z, Zheng S, Yu T, Wu R. Developing BioNavi for Hybrid Retrosynthesis Planning. JACS Au, 2024, 4(7):2492-2502.
Guo S，Zhang Q，Gulikezi·M，YANG Y，Yu T*. Advances in microbial production of liquid biofuels. Synthetic Biology Journal, 2024, 5:1-16.
Tang H#, Wu L#, Guo S#, Cao W, Ma W, Wang X, Shen J, Wang M, Zhang Q, Huang M, Luo X, Zeng J, Keasling J*, Yu T*. Metabolic engineering of carbohydrate-derived foods and chemicals production in yeast. Nature Catalysis, 2024, 7:21-34.
Wang X, Li Y, Jin Z, Liu , Gao X, Guo S*, Yu T*. A novel CRISPR/Cas9 system with high genomic editing efficiency and recyclable auxotrophic selective marker for multiple-step metabolic rewriting in Pichia pastoris. Synthetic and Systems Biotechnology, 2023, 8(3):445-451.
Yu T*, Liu Q, Wang X, Liu X, Chen Y and Nielsen J*. Metabolic reconfiguration enables synthetic reductive metabolism in yeast. Nature Metabolism, 2022, 4(11): 1551-1559.
Zhang H#, Li Z#, Zhou S, Li S, Ran H, Song Z, Yu T & Yin W*. A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringenin. Nature Communications, 2022,13(1):6361.
Zheng T#, Zhang M#, Wu L#, Guo S, Liu X, Zhao J, Xue W,
Li J, Liu C, Li X, Jiang Q, Bao J, Zeng J*, Yu T* and Xia C*. Upcycling CO2 into energy-rich long-chain compounds via
electrochemical and metabolic engineering. Nature Catalysis. 2022, 5:388–396.
Guo S, Wu L, Liu X, Wang B, Yu T*. Developing C1-based metabolic network in methylotrophy for biotransformation. Synthetic Biology Journal, 2022, 3(1):116-137.
Selected Publications (Before joining in SIAT):
Yu T#, Dabirian Y#, Liu Q, Siewers V, Nielsen J*. Strategies and Challenges for Metabolic Rewiring. Current Opinion in Systems Biology, 2019, 15:30-38.
Liu Q., Yu T., Li
X., Chen Y., Campbell K., Nielsen J., Chen Y*. Rewiring carbon metabolism
in yeast for high level production of aromatic chemicals. Nature
Communications, 2019, 10(1):4976.
Yu T#, Zhou Y.J.J#,
Huang M, Liu Q, Pereira R, David F, Nielsen J*. Reprogramming Yeast
Metabolism from Alcoholic Fermentation to Lipogenesis. Cell, 2018, 174(6):1549-1558.
Yu T., Zhou Y.J.J.,
Wenning L., Liu Q.L., Krivoruchko A., Siewers V., Nielsen, J., and David, F*. Metabolic engineering of Saccharomyces cerevisiae for production of very
long chain fatty acid-derived chemicals. Nature Communications, 2017,8:15587.
Yu T., Tao Y., Yang M.,
Chen P., Gao X., Zhang Y., Zhang T., Chen Z., Hou J., Zhang Y., Ruan K., Wang
H., Hu R.G.* Profiling human protein degradome delineates cellular
responses to proteasomal inhibition and reveals a feedback mechanism in
regulating proteasome homeostasis. Cell Research. 2014, 24(10):1214-1230.
[1]Method for detecting protein stability and uses
thereof, Ronggui Hu, Tao Yu, Yonghui
Tao, US20160068861A1.
[2]Fungal cells and methods for production of very long chain
fatty
acid
derived products, Florian
David, Verena
Siewers, Anastasia
KRIVORUCHKO, Leonie
WENNING, Tao Yu, Yong-jin ZHOU,
Jens Nielsen, US20180112240A1.
[3]Yeast strains and construction methods for the synthesis of ferulic acid and its application in the preparation of ferulic acid and piperine metabolites, Zhehao Jin, Tao Yu, CN116622532A.
[5]A recombinant yeast strain for synthesizing aromatic compounds, and its construction method and application, Tao Yu, Zhehao Jin, CN118109326A.
[4]A kind of Saccharomyces cerevisiae engineering strain fermented by glucose-ethanol co-carbon source with high geraniol yield, and its construction method and application, Tao Yu, Zhehao Jin, Xuemei Zhao, Fei Tian, CN117126755A.
