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Patents

甘海云，文青，李欣然，周嘉琦，中国发明专利，“临近标记复合物、临近标记方法、分子间互作分析方法"(专利申请号:CN2021109952378；PCT/CN2021/114989)

专利方法 CN 标记临近

系统管理员 2025-04-28 18:59:29

Research

Unlocking the Epigenetic Code: Synthetic Biology Meets Chromatin Engineering Emerging insights into epigenetic regulation have revealed chromatin-associated pathways as master conductors of cellular identity, aging, and specialization Our laboratory sits at the cutting edge of this revolution, uniquely bridging synthetic biology with epigenetic engineering to reimagine how we understand and manipulate life's molecular control systems We pursue three transformative research frontiers: 1 Designing Epigenetic Control Modules We hunt for nature's hidden toolbox – discovering novel chromatin regulators (including DNA/histone modifiers and epigenetic "switches") – then rewire them into synthetic circuits Like building molecular dimmer switches for genes, we engineer these components to create programmable systems that precisely tune chromatin states, opening new possibilities for controlling cellular behavior 2 Building Smart Cell Factories Imagine microbes or mammalian cells with upgradable "epigenetic software"! We redesign chromatin architecture in industrial cells using synthetic pathways, achieving two breakthroughs: Supercharged Bioproduction: Lock cells into high-performance metabolic states for sustainable chemical synthesis Living Epigenetic Labs: Create cellular models to crack unanswered questions in development and disease 3 Precision Editing of Cellular Memory We pioneer next-generation tools that edit epigenetic marks without altering DNA Our dCas9-based editors act like molecular erasers and pens for chromatin, currently being optimized to: Reset cancer cells by wiping out harmful epigenetic "memories" driving tumor growth Develop safer epigenetic therapies that preserve genome integrity

epigenetic We chromatin cells cellular

系统管理员 2025-04-28 18:44:01

Research

Extrachromosomal DNA (ecDNA) drives the evolution of cancer cells However, the functional significance of ecDNA and the molecular components involved in its replication and maintenance remain largely unknown Here, using CRISPR-C technology, we generated ecDNA-carrying (ecDNA+) cell models By leveraging these models alongside other well-established systems, we demonstrated that ecDNA can replicate and be maintained in ecDNA+ cells The replication of ecDNA activates the ATM-mediated DNA damage response (DDR) pathway Topoisomerases, such as TOP1 and TOP2B, play a role in ecDNA replication-induced DNA double strand breaks (DSBs) A subset of these elevated DSBs persists into the mitotic phase and is primarily repaired by the alternative non-homologous end joining pathway (alt-NHEJ), which involves POLθ and LIG3 Correspondingly, ecDNA maintenance requires DDR, and inhibiting DDR impairs the circularization of ecDNA

ecDNA DNA pathway maintenance DDR

系统管理员 2025-04-28 18:43:07

Assistant Professors

Postdoc Neurophysiology,Michigan State University PhD Biochemistry and Molecular Biology, Northwest University MS Biochemistry and Molecular Biology, Northwest University BS Biotechnology, Northwest University Xing's research interests include: 1) Tumorigenesis: the mechanism of chromosomal instability driving glioma tumorigenesis; 2) Construct the disease model of chromosomal aberrant using human artificial chromosome

University chromosomal Northwest aberrant Neurophysiology

系统管理员 2025-04-25 16:00:52

Assistant Professors

PhD Plant Reproduction and development, Fudan University MS Synthetic Biology, University of Science and Technology of China Yao's research interests include: 1) Epigenetics; Screening potential genes regulating asymmetric histone segregation during DNA replication through rational designed histone tracing circuits 2) Epigenetics in tumor: How parental histones are transmitted to daughter cells in tumor tissue 3) Epigenetics and meiosis: How parental histones are transmitted during meiosis

Epigenetics University histone tumor How

系统管理员 2025-04-25 16:00:52

Visiting Students

MS, Beijing Institute of Technology, Developmental Biology State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences

Institute Biology Beijing Technology Reproductive

系统管理员 2025-04-25 16:02:17

Assistant Professors

PhD Animal Genetics, Breeding and Reproduction, Northwest A&F University MS Animal Nutrition and Feed Science, China Agricultural University Yang's research interests include: 1) Synthetic Epigenetics: De novo construction of epigenetic regulatory modification systems using forward-engineering approaches 2) Epigenetic inheritance: How is parental epigenetic information transmitted to the daughter cells? How distinct chromatin states are inherited following DNA replication? 3) RNA modifications: Is there any transmission of RNA sequences and RNA modifications during DNA replication?

Animal epigenetic University How replication

系统管理员 2025-04-25 16:00:52

Visiting Students

MS, Pharmaceutics, Harbin University of Commerce BS, Pharmaceutical engineering，Suihua University

University Pharmaceutics Harbin Commerce 紫微

系统管理员 2025-04-25 16:02:17

Assistant Professors

PhD Genetics, University of Chinese Academy of Sciences MS Biological Engineering, University of Chinese Academy of Sciences BS Biological Sciences, GuangDong Pharmaceutical University Dr Chen's research interests lies in: 1) Epigenetic regulation of tumor immunity: exploring the roles of epigenetics (mainly histone modifications) in tumor immune response and their applications in cancer therapy 2) Multi-omics researches and applications in cancer immunotherapy: discovering new strategies of tumor immunotherapy through computational genetics and computational immunology

tumor University immunotherapy cancer Sciences

系统管理员 2025-04-25 16:00:52

Assistant Professors

PhD, School of Biological Sciences, The University of Hong Kong MS, Institute of Zoology, Chinese Academy of Sciences MS, University of Chinese Academy of Sciences BS, College of Animal Science and Veterinary Medicine, Jilin University ZHANG's research interests include: 1) molecular biology: fundamental biological processes pertaining to the maintenance and distribution of ecDNA in cancer cells; and 2) tumorigenesis: the role of ecDNA in cancers

University Sciences ecDNA distribution maintenance

系统管理员 2025-04-25 16:00:52