# co-first author *Corresponding authors
2025

Liu C#, Zhao J#, Tang H#, Xue J, Xue W, Li X, Li H, Jiang Q, Zheng T*, Yu T*, Zeng J*, Xia C*. Upcycling surplus acetone into long-chain chemicals using a tandem electro-biosystem. Nature Sustainability, 2025.

Li Y, Wang X, Chen K, Zhuang Z, Tang H, Yu T*, Cao W*. Efficient production of 2′-fucosyllactose in Pichia pastoris through metabolic engineering and constructing an orthogonal energy supply systemSynthetic and Systems Biotechnology, 2025, 10(3):807-815.

Lu X#, Chang M#, Li X#, Cao W, Zhuang Z, Wu Q, Yu T*, Yu A* and Tang H*. Metabolic engineering for sustainable xylitol production from diverse carbon sources in Pichia pastorisMicrobial Cell Factories, 2025, 24: 59.

Chen K#, Maimaitirexiati G#, Zhang Q, Li Y, Liu X, Tang H, Gao X, Wang B*, Yu T*, Guo S*. CRISPR-Cas9-based one-step multiplexed genome editing through optimizing guide RNA processing strategies in Pichia pastoris. Synthetic and Systems Biotechnology, 2025, 10(2): 484-494.

Yang Y, Liu Q, Tian S, Yu T. Research progress in energy metabolism design of cell factoriesChinese Journal of Biotechnology, 2025, 41(3): 1098-1111.

2024

Sun D, Wu L, Lu X, Li C, Xu L, Li H, He D, Yu A, Yu T, Zhao J, Tang H, Bao X. Engineering transcriptional regulatory networks for improving second-generation fuel ethanol production in Saccharomyces cerevisiae. Synthetic and Systems Biotechnology, 2024, 10(1): 207-217.

Zhuang Z#, Wan G#, Lu X, Xie L, Yu T* and Tang H*. Metabolic engineering for single-cell protein production from renewable feedstocks and its applications. Advanced Biotechnology, 2024, 2:35.

Bai Z, Guo S, Yang Y, Zhuang Z, Cao W, Yang Y, Yu T, Tang H. Microbial production of food compounds with carbon dioxide and derived low-carbon molecules as substrates. Chinese Journal of Biotechnology, 2024, 40(8):2731-2746.

Zeng T, Jin Z, Zheng S, Yu T, Wu R. Developing BioNavi for Hybrid Retrosynthesis Planning. JACS Au, 2024, 4(7):2492-2502.

Guo S,Zhang Q,Gulikezi·M,YANG Y,Yu T*. Advances in microbial production of liquid biofuels. Synthetic Biology Journal, 2024, 5:1-16.

Tang H#, Wu L#, Guo S#, Cao W, Ma W, Wang X, Shen J, Wang M, Zhang Q, Huang M, Luo X, Zeng J, Keasling J*, Yu T*. Metabolic engineering of carbohydrate-derived foods and chemicals production in yeast. Nature Catalysis2024, 7:21-34.

2023

Wang X, Li Y, Jin Z, Liu , Gao X, Guo S*, Yu T*A novel CRISPR/Cas9 system with high genomic editing efficiency and recyclable auxotrophic selective marker for multiple-step metabolic rewriting in Pichia pastoris. Synthetic and Systems Biotechnology, 2023, 8(3):445-451.

2022

Yu T*, Liu Q, Wang X, Liu X, Chen Y and Nielsen J*. Metabolic reconfiguration enables synthetic reductive metabolism in yeastNature Metabolism2022, 4(11): 1551-1559.

Zhang H#, Li Z#, Zhou S, Li S, Ran H, Song Z, Yu T & Yin W*. A fungal NRPS-PKS enzyme catalyses the formation of the flavonoid naringeninNature Communications2022,13(1):6361.

Zheng T#, Zhang M#, Wu L#, Guo S, Liu X, Zhao J, Xue W, Li J, Liu C, Li X, Jiang Q, Bao J, Zeng J*, Yu T* and Xia C*. Upcycling CO2 into energy-rich long-chain compounds via electrochemical and metabolic engineering. Nature Catalysis2022,5:388–396.

Guo S, Wu L, Liu X, Wang B, Yu T*. Developing C1-based metabolic network in methylotrophy for biotransformation. Synthetic Biology Journal, 2022, 3(1):116-137.

Selected Publications (Before joining in SIAT):

Yu T#, Dabirian Y#, Liu Q, Siewers V, Nielsen J*. Strategies and Challenges for Metabolic Rewiring.Current Opinion in Systems Biology2019, 15:30-38.

Liu Q., Yu T., Li X., Chen Y., Campbell K., Nielsen J., Chen Y*. Rewiring carbon metabolism in yeast for high level production of aromatic chemicals.Nature Communications, 2019, 10(1):4976.

Yu T#, Zhou Y.J.J#, Huang M, Liu Q, Pereira R, David F, Nielsen J*. Reprogramming Yeast Metabolism from Alcoholic Fermentation to Lipogenesis.Cell2018, 174(6):1549-1558.

Yu T., Zhou Y.J.J., Wenning L., Liu Q.L., Krivoruchko A., Siewers V., Nielsen, J., and David, F*. Metabolic engineering of Saccharomyces cerevisiae for production of very long chain fatty acid-derived chemicals.Nature Communications2017,8:15587.

Yu T., Tao Y., Yang M., Chen P., Gao X., Zhang Y., Zhang T., Chen Z., Hou J., Zhang Y., Ruan K., Wang H., Hu R.G.* Profiling human protein degradome delineates cellular responses to proteasomal inhibition and reveals a feedback mechanism in regulating proteasome homeostasis.Cell Research. 2014, 24(10):1214-1230.