Focusing on key scientific questions about microbial evolution and interacting mechanisms between microbes and corresponding environment, the Center for Quantitative Synthetic Biology (CQSB) has deployed two main research directions, which are theoretical foundation and enabling technology, and conducted extensive explorations in practical applications as well. In order to exploit the combination of quantitative technology and synthetic biology, the center has attracted multidisciplinary and complementary groups from synthetic biology, microbiology, physics, bioinformatics, microfluidics, and proteomics and so on, with more than ten outstanding young Principal Investigators and about 200 researchers.

The development of genomics over the past decade has not only given us a comprehensive and in-depth understanding of the genetic material of various organisms, but also enabled us to open up a treasure trove of precious species and genes. Synthetic genomics was fortunately based on this. It aims to better understand the biological nature of the genome and to systematically analyze the biological functions of the entire genome by designing and reengineering the de novo synthesis method, and to give it new features. Research and application. At present, the center has formed an international research team composed of Jie Qing, Qing Qian, etc., from the Institute of Synthetic Biology, Institute of Advanced Biology, Chinese Academy of Sciences, Institute of synthetic biology, Dr. Dai Junchuang, and Dr. Cai Yizhi, the chief professor of Manchester Manst University. Jointly serving as director, the academician of the New York University School of Medicine Jeff Buka (confirmed Chinese name) serves as honorary director and aims to build a world-class research center for synthetic genomics. The main research directions of the center include: 1. Development of gene and gene combinations into use technology; 2. Genome design and analysis; 3. The application of synthetic biology.

The Center for Synthetic Biochemistry is directed by Jay D. Keasling, an member of National Academy of Engineering.It has gathered many talents in the fields of biology and metabolic engineering. Based on synthetic biology, guided by market demand and regional strategy, the center is committed to the development of new synthetic biochemical theories and methods, and the use of cutting-edge synthetic biology technology to transform the natural metabolism that already exists in nature (plants, fungi, animals) Pathways, and the introduction of engineered microorganisms, based on cheap raw materials to prepare valuable natural or non-natural products.

Using cutting-edge technologies of synthetic biology, the emerging field of Synthetic Microbiome aims to engineer complex microbial communities to achieve desired function and stability. Rational design and precise modulation of microbial communities holds promise for solving important issues in multiple areas, including human health, sustainable agriculture, etc. The Center for Synthetic Microbiome will create an innovative ecosystem to promote basic research of synthetic microbial communities as well as their applications in medicine, agriculture and bio-manufacturing.

Synthetic immunology is an emerging discipline that is highly integrated with cutting-edge immunological theories and modern synthetic biology technology. This has greatly promoted the development of modern theories, technical approaches and product research of immunotherapy for major diseases. The Center for Synthetic Immunology has gathered pioneers and outstanding young talents in synthetic immunology with the aim to cure tumors, autoimmune diseases, viral diseases, organ transplant and other diseases. Our approach is to provide new opportunities to reshape, renormalize, or rebuild the immune system of the body through immunotherapy. The center aims at applying new synthetic immunology theories and approaches to achieve the immunotherapy of major diseases and large-scale industrial production for treatment. At present, the center team is recruiting research groups in many disciplines including immunology, synthetic biology, structural biology, multi-omics and bioinformatics, biomacromolecule drugs, cell-based therapeutics and tissue or organ engineering.

The rapid and concomitant development in frontier methods for the controlled synthesis and characterization of biomaterials at the molecular, nanoscale level, combined with the technological advances in reading and writing genomic, proteomic, metabolomic, and epigenetic information, provide a unique set of opportunities to bring together scientists and engineers from these traditionally disparate fields into a common community. Under such circumstances, Materials Synthetic Biology emerges as a new discipline that lies at the nexus of the physical sciences, life sciences, and engineering, where the tools and tactics of materials science and other engineering principles are used to interrogate, manipulate, and generate new function in biological systems, while at the same time the concepts and components of biology are employed to create new sustainable materials of fundamental interest and societal benefit. Residing in Shenzhen Institute of Synthetic Biology (iSynBio), the newly established Materials Synthetic Biology Center strives to build up an internationally renowned, first-class research hub, where technological innovation and education of the next generation scientists are intimately integrated, and cross-disciplinary collaborations are highly encouraged. The current key research areas of the center include: (1) "Living" functional materials; (2) Semiconductor synthetic biology; (3) Programmable biomaterials and applications in biomedicine, bioenergy and bioelectronics.

Living system requires the fundamental capability to sense and process multiplex input signals, and make accurate cellular decisions. Inspired by the electronic engineering, these biological information processing systems are governed by various gene circuits, including signaling transduction, genetic regulation, metabolic and energetic regulation etc., which may function as the "Central Processor Unit" in synthetic living systems. The understanding of the design principle and regulatory mechanism of natural cell and gene circuits, can uncover the basic law of living system, but also establish the substantial theoretical and technological foundation for the intelligent, automatic control in the next generation of engineering biology. Aiming at the crucial scientific challenges and the cutting-edge biotechnology in synthetic lives, our center will focus on the development of "software" in the design of synthetic lives, to promote interdisciplinary biological science and education. In the next five years, our researches will focus on the following directions: 1) the modular design of key biological parts and devises; 2) the development of computational theories and software for the cell and gene circuits design; 3) the development of smart cell and gene therapeutics.