78. Ohashi, M., D. Tan, J. Lu, C. S. Jamieson, D. Kanayama, J. Zhou^#, K. N. Houk^# and Y. Tang^# (2023) Enzymatic cis-decalin formation in natural product biosynthesis. J Am Chem Soc, 145(6): 3301-3305.【Link】

77.Xu, X.^#, L. Yang, X. Zhang, X. Xing, J. Zhou^# (2023) Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum. Tetrahedron, 130:133174.【Link】

76.Wu P., Y. Gu, L. Liao, Y. Wu, J. Jin, Z. Wang, J. Zhou, S. Shaik^#, B. Wang^# (2022) Coordination Switch Drives Selective C−S Bond Formation by the Non-heme Sulfoxide Synthases. Angew Chem Int Edit, 61(50): e202214235.【Link】

75.Wang L., X. Zang, J. Zhou (2022) Synthetic biology: A powerful booster for future agriculture. Advanced Agarochem,1(1): 7-11.【Link】

74.Zhang, J., X. Hou, Z. Chen, Y. Ko, M. W. Ruszczycky, Y. Chen, J. Zhou^# and H. Liu^# (2022) Dioxane bridge formation during the biosynthesis of spectinomycin involves a twitch radical SAM dehydrogenase that may have evolved from an epimerase. J Am Chem Soc, 144(22): 9910-9919.【Link】

73.Huang, X., J. Feng, J. Cui, G. Jiang, W. Harrison, X. Zang, J. Zhou, B. Wang^# and H. Zhao^# (2022) Photoinduced chemomimetic biocatalysis for enantioselective intermolecular radical conjugate addition. Nat Catal, 5: 586–593.【Link】

72.Zhang, X., Z. Xu, J. Zhou, X. Xing^# and L. Li^# (2022) Enhancement of protein crystallization using nano-sized metal–organic framework. Crystals, 12(5): 578.【Link】

70.Jin, J., J. Zhou (2022) The mystery of Z-genome biosynthesis has been elucidated. Syn Bio J, 3(1): 1-5.【Link】

69.Chen, T., Z. Zheng, X. Zhang, J. Chen, L. Cha, Y. Tang, Y. Guo^#, J. Zhou^#, B. Wang^#, H. Liu^# and W. Chang^# (2022) Deciphering the reaction pathway of mononuclear iron enzyme-catalyzed N≡C triple bond formation in isocyanide lipopeptide and polyketide biosynthesis. Acs Catal, 12(4): 2270-2279.【Link】

68.Wu, L., Z. Wang, Y. Cen^#, B. Wang^# and J. Zhou^# (2022) Structural insight into the catalytic mechanism of the endoperoxide synthase FtmOx1. Angew Chem Int Ed Engl, 61(12): e202112063.【Link】

67.Cheng, Q., Y. Cheung, C. Liu, Q. Xiao, B. Sun, J. Zhou, E. W. C. Chan, R. Zhang and S. Chen (2021) Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. BMC Biol, 19(1): 262.【Link】

65.Li, S., P. D. Bury, F. Huang, J. Guo, G. Sun, A. Reva, C. Huang, X. Jian, Y. Li, J. Zhou, Z. Deng, F. J. Leeper^#, P. F. Leadlay^#, M. V. B. Dias^# and Y. Sun^# (2021) Mechanistic insights into dideoxygenation in gentamicin biosynthesis. Acs Catal, 11(19): 12274-12283.【Link】

64.Xie, L., X. Zang, W. Cheng, Z. Zhang, J. Zhou^#, M. Chen^# and Y. Tang^# (2021) Harzianic acid from Trichoderma afroharzianum is a natural product inhibitor of acetohydroxyacid synthase. J Am Chem Soc, 143(25): 9575-9584.【Link】

63.Xiang, M. Wang, Wu, Z. Lu, J. Tang, J. Zhou, W. Huang^#, and G. Zhang^# (2021) Structural insights into xylanase mutant 254RL1 for improved activity and lower pH optimum, Enzyme Microb Technol, 147: 109786.【Link】

62.Liu, N., L. Wu, J. Feng, X. Sheng^#, J. Li, X. Chen, J. Li, W. Liu, J. Zhou^#, Q. Wu^#, and D. Zhu^# (2021) Crystal structures and catalytic mechanism of L-erythro-3,5-diaminohexanoate dehydrogenase and rational engineering for asymmetric synthesis of β-amino acids, Angew Chem Int Ed, 60: 10203-10.【Link】

61.Gao, D., C. S. Jamieson, G. Wang, Y. Yan, J. Zhou^#, K. N. Houk^#, and Y. Tang^# (2021) A polyketide cyclase that forms medium-ring lactones. J Am Chem Soc, 143: 80-84.【Link】

60.Chen, T., J. Chen, Y. Tang, J. Zhou^#, Y. Guo^# and W. Chang^# (2021) Current understanding toward isonitrile group biosynthesis and mechanism. Chin J Chem, 39(2): 463-472.【Link】

59.Yan, Y., X. Zang, C. S. Jamieson, H. Lin, K. N. Houk, J. Zhou^# and Y. Tang^# (2020) Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance. Chem Sci, 11(35): 9554-9562.【Link】

58.Ohashi, M., C. S. Jamieson, Y. Cai, D. Tan, D. Kanayama, M. C. Tang, S. M. Anthony, J. V. Chari, J. S. Barber, E. Picazo, T. B. Kakule, S. Cao, N. K. Garg, J. Zhou^#, K. N. Houk^# and Y. Tang^# (2020) An enzymatic Alder-ene reaction. Nature, 586: 64-69.【Link】

57.Chen, C., L. Su^#, L. Wu, J. Zhou and J. Wu^# (2020) Enhanced the catalytic efficiency and thermostability of maltooligosyltrehalose synthase from Arthrobacter ramosus by directed evolution. Biochem Eng J, 162: 107724.【Link】

56.Cheng, R., L. Wu, R. Lai, C. Peng, N. Naowarojna, W. Hu, X. Li, S. A. Whelan, N. Lee, J. Lopez, C. Zhao, Y. Yong, J. Xue, X. Jiang, M. W. Grinstaff, Z. Deng, J. Chen, Q. Cui^#, J. Zhou^# and P. Liu^# (2020) Single-step replacement of an unreactive C-H bond by a C-S bond using polysulfide as the direct sulfur source in anaerobic ergothioneine biosynthesis. ACS Catal, 10(16): 8981-8994.【Link】

55.Dong, Q., S. Yuan, L. Wu, L. Su, Q. Zhao, J. Wu, W. Huang^# and J. Zhou^# (2020) Structure-guided engineering of a Thermobifida fusca cutinase for enhanced hydrolysis on natural polyester substrate. Bioresour and Bioprocess, 7(1): 49.【Link】

54.Yang, X., L. Wu, A. Li, L. Ye^#, J. Zhou^# and H. Yu^# (2020) The engineering of decameric D-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions. Chem Commun (Camb), 56(55): 7561-7564.【Link】

53.Li, A., C. G. Acevedo-Rocha, L. D'Amore, J. Chen, Y. Peng, M. Garcia-Borras, C. Gao, J. Zhu, H. Rickerby,S. Osuna^#, J. Zhou^# and M. T. Reetz^# (2020) Regio- and stereoselective steroid hydroxylation at C7 by cytochrome P450 monooxygenase mutants. Angew Chem Int Ed Engl, 59(30): 12499-12505.【Link】

52.Chen, T., J. Chen, Y. Tang, J. Zhou^#, Y. Guo^# and W. Chang^# (2020) Pathway from N-alkylglycine to alkylisonitrile catalyzed by Iron (II) and 2-oxoglutarate-dependent oxygenases. Angew Chem Int Ed Engl, 59(19): 7367-7371.【Link】

51.Cai, Y., Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk^#, J. Zhou^# and Y. Tang^# (2019) Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat Chem, 11(9): 812-820.【Link】

50.Cen, Y., W. Singh, M. Arkin, T. S. Moody, M. Huang, J. Zhou^#, Q. Wu^# and M. T. Reetz^# (2019) Artificial cysteine-lipases with high activity and altered catalytic mechanism created by laboratory evolution. Nat Commun, 10(1): 3198.【Link】

49.Xu, J., Y. Cen, W. Singh, J. Fan, L. Wu, X. Lin, J. Zhou^#, M. Huang^#, M. T. Reetz^# and Q. Wu^# (2019) Stereodivergent protein engineering of a lipase to access all possible stereoisomers of chiral esters with two stereocenters. J Am Chem Soc, 141(19): 7934-7945.【Link】

48.Zhou, J., Y. Wang, G. Xu, L. Wu, R. Han, U. Schwaneberg, Y. Rao, Y. L. Zhao, J. Zhou^# and Y. Ni^# (2018) Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a "polar gate" in stereorecognition of diaryl ketones. J Am Chem Soc, 140(39): 12645-12654.【Link】

47.Yan, Y., Q. Liu, X. Zang, S. Yuan, U. Bat-Erdene, C. Nguyen, J. Gan, J. Zhou^#, S. E. Jacobsen^# and Y. Tang^# (2018) Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature, 559(7714): 415-418.【Link】

46.Li, Y., W. Zhang, H. Zhang, W. Tian, L. Wu, S. Wang, M. Zheng, J. Zhang, C. Sun, Z. Deng, Y. Sun, X. Qu^# and J. Zhou^# (2018) Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angew Chem Int Ed Engl, 57(20): 5823-5827.【Link】

45.Sun, Z., L. Wu, M. Bocola, H. C. S. Chan, R. Lonsdale, X. D. Kong, S. Yuan^#, J. Zhou^# and M. T. Reetz^# (2018) Structural and computational insight into the catalytic mechanism of limonene epoxide hydrolase mutants in stereoselective transformations. J Am Chem Soc, 140(1): 310-318.【Link】

44.Yuan, H., J. Zhang, Y. Cai, S. Wu, K. Yang, H. C. S. Chan, W. Huang, W. B. Jin, Y. Li, Y. Yin, Y. Igarashi, S. Yuan^#, J. Zhou^# and G. Tang^# (2017) GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat Commun, 8(1): 1485.【Link】

43.Li, M., Z. Zhang, X. Kong, H. Yu, J. Zhou^# and J. Xu^# (2017) Engineering streptomyces coelicolor carbonyl reductase for efficient atorvastatin precursor synthesis. Appl Environ Microbiol, 83(12): e00603-17.【Link】

42.Zhang, J., N. Liu, R. A. Cacho, Z. Gong, Z. Liu, W. Qin, C. Tang, Y. Tang^# and J. Zhou^# (2016) Structural basis of nonribosomal peptide macrocyclization in fungi. Nat Chem Biol, 12(12): 1001-1003.【Link】

41.Chen, W., Y. Li, J. Li, L. Wu, Y. Li, R. Wang, Z. Deng^# and J. Zhou^# (2016) An unusual UMP C-5 methylase in nucleoside antibiotic polyoxin biosynthesis. Protein Cell, 7(9): 673-683.【Link】

40.Zhu, H., G. Xu, K. Zhang, X. Kong, R. Han, J. Zhou^# and Y. Ni^# (2016) Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding. Sci Rep, 6: 27779.【Link】

39.Zhou, M., L. Xie, Z. Yang, J. Zhou^# and J. Xie^# (2017) Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics. J Biomol Struct Dyn, 35(5): 1030-1041.【Link】

38.Sun, Z., R. Lonsdale, A. Ilie, G. Li, J. Zhou and M. T. Reetz (2016) Catalytic asymmetric reduction of difficult-to-reduce ketones: triple-code saturation mutagenesis of an alcohol dehydrogenase. ACS Catal, 6(3): 1598-1605.【Link】

37.Sun, Z., R. Lonsdale, L. Wu, G. Li, A. Li, J. Wang, J. Zhou^# and M. T. Reetz^# (2016) Structure-guided triple-code saturation mutagenesis: efficient tuning of the stereoselectivity of an epoxide hydrolase. Acs Catal, 6(3): 1590-1597.【Link】

36.Luan, Z., F. Li, S. Dou, Q. Chen, X. Kong, J. Zhou, H. Yu^# and J. Xu^# (2015) Substrate channel evolution of an esterase for the synthesis of cilastatin. Catal Sci & Technol, 5(5): 2622-2629.【Link】

35.Kong, X., H. Yu, S. Yang, J. Zhou, B. Zeng and J. Xu (2015) Chemoenzymatic synthesis of (R)- and (S)-propranolol using an engineered epoxide hydrolase with a high turnover number. Journal of Molecular Catalysis B: Enzymatic, 122: 275-281.【Link】

34.Chen, J., X. Luo, Q. Chen, J. Pan^#, J. Zhou and J. Xu^# (2015) Marked enhancement of Acinetobacter sp. organophosphorus hydrolase activity by a single residue substitution Ile211Ala. Bioresour and Bioprocess, 2(1): 39.【Link】

33.Sun, Z., R. Lonsdale, X. Kong, J. Xu, J. Zhou^# and M. T. Reetz^# (2015) Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution.Angew Chem Int Edit, 54(42): 12410-12415.【Link】

32.Kong, X., S. Yuan, L. Li, S. Chen, J. Xu^# and J. Zhou^# (2014) Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci U S A, 111(44): 15717-15722.【Link】

31.Kong, X., Q. Ma, J. Zhou^#, B. Zeng^# and J. Xu^# (2014) A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors. Angew Chem Int Ed Engl, 53(26): 6641-6644.【Link】

30.Luo, X., X. Kong, J. Zhao, Q. Chen, J. Zhou^# and J. Xu^# (2014) Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnol Bioeng, 111(10): 1920-1930.【Link】

29.Sun, Y., S. Yin, Y. Feng, J. Li, J. Zhou, C. Liu, G. Zhu and Z. Guo (2014) Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad. J Biol Chem, 289(22): 15867-15879.【Link】

28.Dou, S., X. Kong, B. Ma, Q. Chen, J. Zhang, J. Zhou^# and J. Xu^# (2014) Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochem Biophys Res Commun, 446(4): 1145-1150.【Link】

27.Li, J., C. Wang, Z. Zhang, Y. Cheng^# and J. Zhou^# (2014) The structural basis of an NADP(+)-independent dithiol oxidase in FK228 biosynthesis. Sci Rep-Uk, 4: 4145.【Link】

26.Zhang, Z., F. Yang, J. Zhang, Q. Tang, J. Li, J. Gu, J. Zhou^# and Y. Xu^# (2013) Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5(5): 1269-1278.【Link】

25.Xu, Z., S. Li, J. Li, Y. Li, X. Feng, R. Wang, H. Xu^# and J. Zhou^# (2013) The structural basis of erwinia rhapontici isomaltulose synthase. Plos One, 8(9): e74788.【Link】

24.Ma, J., L. Wu, F. Guo, J. Gu, X. Tang, L. Jiang, J. Liu, J. Zhou^# and H. Yu^# (2013) Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl Microbiol Biot, 97(11): 4897-4906.【Link】

23.Yang, F., X. Wang, Z. Zhang, J. Pu, Y. Fan, J. Zhou, C. C. Query and Y. Xu (2013) Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Res, 41(8): 4660-4670.【Link】

22.Sun, Y., H. Song, J. Li, Y. Li, M. Jiang, J. Zhou^# and Z. Guo^# (2013) Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily. PLoS One, 8(4): e63095.【Link】

21.Zhang, Z., X. Zhang, Z. Zhou, H. Hu, M. Liu, B. Zhou^# and J. Zhou^# (2013) Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t. J Biomol Nmr, 55(2): 219-223.【Link】

20.Kong X., H. Yu, J. Zhou, J. Xu (2013) Structure basis of EHs and development of novel EHs as biocatalyst. Chin J Biomed Eng, 11(01): 77-86.【Link】

19.Sun, Y., H. Song, J. Li, M. Jiang, Y. Li, J. Zhou^# and Z. Guo^# (2012) Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways. Biochemistry, 51(22): 4580-4589.【Link】

18.Diao, L., Q. Dong, Z. Xu, S. Yang, J. Zhou^# and R. Freudl^# (2012) Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in Bacillus subtilis. Appl Environ Microb, 78(3): 651-659.【Link】

17.Cai, C., L. Wu, C. Li, P. He, J. Zhou and J. Li (2011) Purification, crystallization and preliminary X-ray analysis of phycocyanin and phycoerythrin from Porphyra yezoensis Ueda. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67(5): 579-583.【Link】

16.Zhou, B., X. Li, Y. Li, Y. Xu, Z. Zhang, M. Zhou, X. Zhang, Z. Liu, J. Zhou, C. Cao, B. Yu and R. Wang (2011) Discovery and development of thiazolo [3,2-a] pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins. ChemMedChem, 6(5): 904-921.【Link】

15.Tao, W., Z. Gao, Z. Gao, J. Zhou, Z. Huang, Y. Dong and S. Yu (2011) The 1.6Å resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer. Int J Biol Macromol, 48(3): 459-465.【Link】

14.Ren, A., Z. Xia, W. Yu and J. Zhou (2010) Expression, crystallization and preliminary X-ray analysis of an anomeric inverting agarase from Pseudoalteromonas sp. CY24. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(12): 1635-1639.【Link】

13.Ma, H., J. He, X. Liu, J. Gan, G. Jin and J. Zhou (2010) Surface initiated polymerization from substrates of low initiator density and its applications in biosensors. ACS Appl Mater Interfaces, 2(11): 3223-3230.【Link】

12.Zhu, C., X. Li, W. Li, Z. Shi, J. Zhou, R. Wang (2010) Expression, purification and activity analysis of three Bcl-2 family proteins. J Biomedl Eng, 27(4): 834-841.【Link】

11.Zheng, C., H. Liu, S. Yuan, J. Zhou and B. Zhang (2010) Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII. Blood, 116(25): 5698-5706.【Link】

10.Zheng, C., H. Liu, J. Zhou and B. Zhang (2010) EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII. Blood, 115(5): 1081-1087.【Link】

9.Han, C., T. Hu, D. Wu, S. Qu, J. Zhou, J. Ding, X. Shen, D. Qu and H. Jiang (2009) X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. FEBS J, 276(4): 1125-1139.【Link】

8.Lai, L., Z. Xu, J. Zhou, K. D. Lee and G. L. Amidon (2008) Molecular basis of prodrug activation by human valacyclovirase, an α-amino acid ester hydrolase. J Biol Chem, 283(14): 9318-9327.【Link】

7.Xiao, J., H. Xia, J. Zhou, I. F. Azmi, B. A. Davies, D. J. Katzmann and Z. Xu (2008) Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell, 14(1): 37-49.【Link】

6.Xiao, J., H. Xia, K. Yoshino-Koh, J. Zhou and Z. Xu (2007) Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol, 374(3): 655-670.【Link】

5.Zhou, J.^*, C. Liu^*, S. H. Back, R. L. Clark, D. Peisach, Z. Xu^# and R. J. Kaufman^# (2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A, 103(39): 14343-14348.【Link】

4.Zhou, J., Z. Xu (2005) The structural view of bacterial translocation-specific chaperone SecB: implications for function. Mol Microbiol, 58(2): 349-357.【Link】

3.Zhou, J., Z. Xu (2003). Structural determinants of SecB recognition by SecA in bacterial protein translocation. Nat Struct Biol, 10(11): 942-947.【Link】

2.Wang, Y.^*, J. Zhou^*, Y. Wang, J. Bao and H. Chen (2001) Properties of hybrid enzymes between Synechococcus large subunits and higher plant small subunits of ribulose-1,5-bisphosphate carboxylase/oxygenase in Escherichia coli. Arch Biochem Biophys, 396(1): 35-42.【Link】

1. Zhou, J., H. Chen (2000) A facile DNA shuffling protocol. Prog Biochem Biophys, 27(6): 655-657.【Link】