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Research Assistant Professor & Postdocs

PhD Karolinska Institute Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Institute Advanced Ph Karolinska Shenzhen

梁桐荧 2026-04-09 15:56:17

Graduate Students

Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Shenzhen Advanced Institute Technology 骄阳

梁桐荧 2026-03-28 08:58:52

Research Assistant Professor & Postdocs

PhD Xiamen University Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences

Advanced Xiamen Institute University Shenzhen

系统管理员 2026-03-27 20:55:42

Papers

*:corresponding author #:co-first author Qisi Zhang, Longlong Si* Live vaccine development through targeted protein degradationNatureReviewsImmunology2025,doi: 101038/s41577-025-01212-y Jinying Shen#, Jing Li#, Quan Shen#, Jihuan Hou#, Chunhe Zhang#, Haiqing Bai#, Xiaoni Ai#, Yinlei Su, Zihao Wang, Yunfei Zhang, Beibei Xu, Jiawei Hao, Ping Wang, Qisi Zhang, Adam Yongxin Ye, Zhen Li, Tang Feng, Le Li, Fei Qi, Qikai Wang, Yacong Sun, Chengyao Liu, Xuetong Xi, Lei Yan, Hanhui Hong, Yuting Chen, Xin Xie, Jing Xie, Xiaoheng Liu, Ruikun Du, Roberto Plebani, Lihe Zhang, Demin Zhou, George Church, Longlong Si* Proteolysis-targeting influenza vaccine strains induce broad-spectrum immunity and in vivo protection Nature Microbiology 2025, doi: 101038/s41564-024-01908-2 Chunhe Zhang#, Jihuan Hou#, Zhen Li#, Quan Shen#, Haiqing Bai#, Li Chen#, Jinying Shen#, Ping Wang#, Yinlei Su, Jing Li, Qisi Zhang, Chengyao Liu, Xuetong Xi, Fei Qi, Yuting Chen, Xin Xie, Adam Yongxin Ye, Xiaoheng Liu, Roberto Plebani, George Church, Longlong Si* PROTAR Vaccine 20 generates influenza vaccines by degrading multiple viral proteins Nature Chemical Biology2025, doi: 101038/s41589-024-01813-z Le Tong#,*, Weiyingqi Cui, Boya Zhang, Pedro Fonseca, Qian Zhao, Ping Zhang, Beibei Xu, Qisi Zhang, Zhen Li, Brinton Seashore-Ludlow1, Ying Yang, Longlong Si*, Andreas Lundqvist* Patient-derived organoids in precision cancer medicine Med 2024, 5 (11), 1351-1377 Longlong Si#,*, Quan Shen#, Jing Li#, Li Chen, Jinying Shen, Xue Xiao, Haiqing Bai, Tang Feng, Adam Yongxin Ye, Le Li, Chunhe Zhang, Zhen Li, Ping Wang, Crystal Yuri Oh, Atiq Nurani, Siwen Niu, Chengxin Zhang, Xiaoqiong Wei, Wanqiong Yuan, Hao Liao, Xiaojie Huang, Ning Wang, Wen-xia Tian, Hongwei Tian, Li Li, Xiaoheng Liu, Roberto Plebani Generation of a live attenuated influenza A vaccine by proteolysis targeting Nature Biotechnology 2022, doi: 10 1038/s41587-022-01381-4 Haiqing Bai#, Longlong Si#,Amanda Jiang, Chaitra Belgur, Yunhao Zhai, Roberto Plebani, Crystal Yuri Oh, Melissa Rodas, Aditya Patil, Atiq Nurani, Sarah E Gilpin, Rani K Powers, Girija Goyal, Rachelle Prantil-Baun, Donald E Ingber* Mechanical control of innate immune responses against viral infection revealed in a human lung alveolus chip Nature Communications 2022, 13 (1): 1928 Longlong Si#, Haiqing Bai#, Crystal Yuri Oh, Amanda Jiang, Fan Hong, Tian Zhang, Yongxin Ye, Tristan X Jordan, James Logue, Marisa McGrath, Chaitra Belgur, Karina Calderon, Atiq Nurani, Wuji Cao, Kenneth E Carlson, Rachelle Prantil-Baun, Steven P Gygi, Dong Yang, Colleen B Jonsson, Benjamin R tenOever, Matthew Frieman, Donald E Ingber* Self-assembling short immunostimulatory duplex RNAs with broad spectrum antiviral activity Molecular Therapy-Nucleic Acids 2022, doi: 10 1016/jomtn202208031 Longlong Si#, Haiqing Bai#, Melissa Rodas, Wuji Cao, Crystal Yuri Oh, Amanda Jiang, Rasmus Moller, Daisy Hoagland, Kohei Oishi, Shu Horiuchi, Skyler Uhl, Daniel Blanco-Melo, Randy A Albrecht, Wen-Chun Liu,Tristan Jordan, Benjamin E Nilsson-Payant, Ilona Golynker, Justin Frere, James Logue, Robert Haupt, Marisa McGrath, Stuart Weston, Tian Zhang, Roberto Plebani, Mercy Soong, Atiq Nurani, Seong Min Kim, Danni Y Zhu, Kambez H Benam, Girija Goyal, Sarah E Gilpin, Rachelle Prantil-Baun, Steven P Gygi, Rani K Powers, Kenneth E Carlson, Matthew Frieman, Benjamin R TenOever, Donald E Ingber* A human-airway-on-a-chip for the rapid identification of candidate antiviral therapeutics and prophylactics Nature Biomedical Engineering 2021, 5 (8), 815-829 Longlong Si#, Haiqing Bai#, Crystal Yuri Oh, Lei Jin, Rachelle Prantil-Baun, Donald E Ingber* Clinically Relevant Influenza Virus Evolution Reconstituted in a Human Lung Airway-on-a-Chip Microbiology Spectrum 2021, 9 (2), e00257-21 6 Longlong Si, Kun Meng, Zhenyu Tian, Jiaqi Sun, Huiqiang Li, Ziwei Zhang, Veronica Soloveva, Haiwei Li, Ge Fu, Qing Xia, Sulong Xiao, Lihe Zhang, Demin Zhou* Triterpenoids manipulate a broad range of virus-host fusion via wrapping the HR2 domain prevent in viral envelopes Science Advances 2018, 4, eaau8408 DOI: 10 1126/sciadvaau8408 Longlong Si#, Huan Xu#, Xueying Zhou, Ziwei Zhang, Zhenyu Tian, Yiming Wu, Bo Zhang, Yan Wang,Zhenglan Niu, Chuanling Zhang, Ge Fu, Sulong Xiao, Qing Xia, Lihe Zhang, Demin Zhou* Generation of influenza A viruses as live but replication-incompetent virus vaccines Science 2016, 354, 1170- 1173

Zhang Longlong Li Nature Wang

系统管理员 2025-04-25 14:50:06

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系统管理员 2025-04-25 14:30:46

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系统管理员 2025-04-25 14:30:19

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系统管理员 2025-04-25 14:29:39

Professor

司龙龙博士，中国科学院深圳先进技术研究院合成生物学研究所研究员、博士生导师，定量合成生物学全国重点实验室副主任，国家高层次人才（青年），国家重点研发计划首席科学家，2024年入选全球前2%顶尖科学家榜单（美国斯坦福大学与爱思唯尔数据库（Elsevier）联合发布）。博士毕业于北京大学，在哈佛大学Wyss研究所、哈佛医学院完成博士后研究工作。实验室主要研究方向为“病毒感染及防治研究的新策略和新系统的开发及应用”，包括合成生物学驱动的疫苗技术开发、人体器官体外仿生系统“人体器官芯片”、抗病毒药物的开发。发表论文约50篇，其中代表性研究成果以通讯作者、第一作者（含共同一作）发表于Science、 Nature Biotechnology、Nature Microbiology、Nature Biomedical Engineering、Nature Chemical Biology、Science Advances、Nature Communications等专业期刊，申请和授权专利20余项。部分研究工作获 “中国科学十大进展”、“国际疫苗学会-年度论文”、Wyss Technology Development Fellowship等荣誉奖励。联系邮箱：llsi@siataccn Longlong Si is a professor in the Institute of Synthetic Biology at Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences (CAS), and the associated director of State Key Laboratory of Quantitative Synthetic Biology Before joining SIAT, he was a Wyss Technology Development Fellow and postdoctoral research fellow in the Wyss Institute for Biologically Inspired Engineering at Harvard University and Harvard Medical School He received his PhD in Chemical Biology from Peking University and his bachelor’s degree in Pharmacy from West China School of Pharmacy, Sichuan University Si Lab’s research interests lie at the interface of synthetic biology and virology/vaccinology/biomedical engineering, and they have focused on Synthetic Biology-Inspired Virus Engineering for Medical Innovation, Human Organ-on-a-Chip Technology Development and Applications, as well as Translating the Innovations into Commercial Products He has authored about 50 publications and his representative accomplishments have been published in Science, Nature Biotechnology, Nature Microbiology, Nature Biomedical Engineering, Nature Chemical Biology, Science Advances, Nature Communications etc He has filed more than 20 patents, including antiviral drugs that are under testing in Phase II clinical trial Part of the findings and technologies were awarded “Top 10 Scientific Progress of China in 2017”, “International Society for Vaccines (ISV)-Paper of the Year”, and “Wyss Technology Development Fellowship” In 2024, he was included in "World's Top 2% Scientist List" released by Standford University and Elsevier Email: llsi@siataccn

Technology Wyss University Biology Development

系统管理员 2025-04-25 17:01:52

RESEARCH

Medical Virus Engineering Biology-Inspired Synthetic

系统管理员 2025-04-25 14:40:33

RESEARCH

Human Organ-on-a-Chip Technology Development and Applications We leverage the human organ-on-a-chip technology to faithfully mimic human organs and recapitulate human organ-level physiology and pathophysiology in vitro, enabling faster, better, and cheaper drug development, insights into human health, and personalized medicine

human Applications We leverage insights

系统管理员 2025-04-25 14:42:03