论文列表

98. Zhi-Pu Li, Lanteng Wang, Yan Liu, Xiao-Qiong Pei, M. Qaiser Fatmi, Zhuanglin Shen, Jian Zhao, Hui Lin, Jiahai Zhou, Zhong-Liu Wu, Angew. Chem. Int. Ed. 2025, e202423117. 【link】

97. Sun, Z.; Zang, X.; Zhou, Q.; Ohashi, M.; Houk, K. N.^#; Zhou, J.^#; Tang, Y.^# Iminium Catalysis in Natural Diels-Alderase. Nat. Catal. 2025. https://doi.org/10.1038/s41929-025-01294-w. 【link】

96.

Jia-Jing Li,

Xiao-Jian Zhou,

Juan Ao,

Jin-Tao Gao,

An-Ni Wang,

Zhuang-Lin Shen,

Yang Gu,

Jia-Hai Zhou,

Yong-Zheng Chen*

. (2024) . P450DA Monooxygenase-Catalyzed Chemoselective and Enantiodivergent Epoxidation of Unactivated Alkenes. ACS Catalysis . 14, (21), 16175–16183. 【link】

95. Xin Zang, Undramaa Bat-Erdene, Weixue Huang, Zhongshuo Wu, Steve E Jacobsen, Yi Tang^#, Jiahai Zhou^#. (2024) Structural bases of dihydroxy acid dehydratase inhibition and biodesign for self-resistance. BioDesign Research. 【link】

94. Hou X, Feng J, Franklin JL, Russo R, Guo Z, Zhou J^#, Gao JM^#, Liu HW^#, Wang B^#. (2024) Mechanistic Insights from the Crystal Structure and Computational Analysis of the Radical SAM Deaminase DesII. Adv Sci. 28: e2403494. 【link】

93. Qian Tang, Yuxin Huang, Zhuanglin Shen, Linhui Sun, Yang Gu, Huiqing He, Yanhong Chen, Jiahai Zhou , Limin Zhang, Cuihuan Zhao, Shisong Ma, Yunhai Li, Jie Wu ^# , Qiao Zhao ^# (2024) 6-Phosphogluconate dehydrogenase 2 bridges the OPP and shikimate pathways to enhance aromatic amino acid production in plants. SCIENCE CHINA Life Sciences‍(Online ahead of print)

92. Jie Wu, Yanhong Chen, Yuxin Huang, Bingbing Hao, Shengkun Dai, Lingling Zhao, Zhehui Zhao, Cuihuan Zhao, Limin Zhang, Yunhai Li, Xuexia Xu, Nan Li, Ancheng C. Huang, Jiahai Zhou, Minjia Tan, Wentao Zhu*, Qiao Zhao* (2024) Cytosolic aminotransferase VAS1 coordinates aromatic amino acids biosynthesis and metabolism. Sci Adv 10(2): eadk0738. 【Link】

91. Dhanaraju Mandalapu, Xinjian Ji, Jinfeng Chen, Chuchu Guo, Wan-Qiu Liu, Wei Ding, Jiahai Zhou, Qi Zhang ^# . ( 2018) Thioesterase-Mediated Synthesis of Teixobactin Analogues: Mechanism and Substrate Specificity. J Org Chem. 83 (13): 7271-7275. 【Link】

90. Wan, Zheng, Man Shi, Yanqing Gong, Massimo Lucci, Jinjin Li, Jiahai Zhou, Xiao-Liang Yang^#, Moreno Lelli^#, Xiao He^#, and Jiafei Mao^#. (2024) Multitasking Pharmacophores Support Cabotegravir-Based Long-Acting HIV Pre-Exposure Prophylaxis (PrEP). Molecules, 29 (2): 376. 【Link】

89. Tzu-Yu Chen, Jinfeng Chen, Mark W. Ruszczycky, Dalton Hilovsky, Tyler Hostetler, Xiaojing Liu ^# , Jiahai Zhou ^# , and Wei-chen Chang ^# (2024). Variation in Biosynthesis and Metal-Binding Properties of Isonitrile-Containing Peptides Produced by Mycobacteria versus Streptomyces. Acs Catal, 14, 4975–4983. 【Link】

88. Jie Zheng, Zhuanglin Shen, Jin-Ming Gao ^#, Jiahai Zhou ^#, and Yang Gu ^#. (2023） Enzymatic Photodecarboxylation on Secondary and Tertiary Carboxylic Acids . Org. Lett. https://doi.org/10.1021/acs.orglett.3c03356 【Link】

87. Xiaolin Zou, Zhen Hui, Robert A. Shepherd, Shuaiqiang Zhao, Yanfei Wu, Zhuanglin Shen, Cuiping Pang, Shipeng Zhou, Zehai Yu, Jiahai Zhou, Bradly S. Moore, Laura M. Sanchez, Xiaoyu Tang ^# .（2023） Unveiling a CAAX Protease-Like Protein Involved in Didemnin Drug Maturation and Secretion . Adv. Sci. 2023 , 2306044. 【Link】

86. Jingkun Shi, Xin Zang, Zhijie Zhao, Zhuanglin Shen, Wei Li, Guiyun Zhao, Jiahai Zhou^#, and Yi-Ling Du*. 2023 Conserved Enzymatic Cascade for Bacterial Azoxy Biosynthesis . J. Am. Chem. Soc .

https://doi.org/10.1021/jacs.3c12018

【Link】

85. Yuanyuan Huang, Yanfei Wu, Han Hu, Bangzhuo Tong, Jie Wang, Siyu Zhang, Yanyi Wang, Jicong Zhang, Yue Yin, Shengkun Dai, Wenjuan Zhao, Bolin An, Jiahua Pu, Yaomin Wang, Chao Peng, Nan Li, Jiahai Zhou^#, Yan Tan ^#, Chao Zhong^# . (2023) Accelerating the design of pili-enabled living materials using an integrative technological workflow. Nat Chem Biol. https://doi.org/10.1038/s41589-023-01489-x 【Link】

84. Wu L., Wang Z., Cen Y.^#, Wang B.^#, Zhou J.^# (2023). Reply to Correspondence on “Structural Insight into the Catalytic Mechanism of the Endoperoxide Synthase FtmOx1”. Angew Chem Int Edit, 62, e202306059. 【Link】

83.

Jun-Bin He,

Lian Wu,

Wanqing Wei,

Song Meng,

Zheng-Tao Liu,

Xuan Wu,

Hai-Xue Pan,

Sheng Yang,

Yong Liang^#,

Jiahai Zhou^#,

Gong-Li Tang^#. (2023). Enzymatic catalysis favours eight-membered over five-membered ring closure in bicyclomycin biosynthesis. Nat Catal, 6, 637–648. 【Link】

82. Yang, Qin, Zhenkun Zhang, Lin Wang, Xiwen Xing^#, Jiahai Zhou^#, and Long Li^#. (2023). Preparation and Characterization of Metal–Organic Framework Coatings for Improving Protein Crystallization Screening. Nanomaterials, 13(14): 2064. 【Link】

81. Dong-Dong Wu, Sheng Jin, Ruo-Xiao Cheng, Wen-Jie Cai^#, Wen-Long Xue, Qing-Qing Zhang, Le-Jie Yang, Qi Zhu, Meng-Yao Li, Ge Lin, Yi-Zhen Wang, Xue-Pan Mu, Yu Wang, Igor Ying Zhang, Qi Zhang, Ying Chen, Sheng-Yang Cai, Bo Tan, Ye Li, Yun-Qian Chen, Pu-Juan Zhang, Chen Sun, Yue Yin, Ming-Jie Wang, Yi-Zhun Zhu, Bei-Bei Tao, Jia-Hai Zhou^#, Wei-Xue Huang^#, and Yi-Chun Zhu^#. (2023). Hydrogen sulfide functions as a micro-modulator bound at the copper active site of Cu/Zn-SOD to regulate the catalytic activity of the enzyme. Cell Reports, 42, (7): 112750. 【Link】

80. Liu J., Lu J., Zhang C., Zhou Q., Jamieson C.S., Shang C., Houk K.N. ^#, Zhou J. ^#, Hu Y. ^#(2023). Tandem intermolecular [4 + 2] cycloadditions are catalysed by glycosylated enzymes for natural product biosynthesis. Nat. Chem. 15, 1083–1090. 【Link】

79. Xu X. ^# , Yang Q., Wang L., Zheng J., Gu Y., Xing X. ^# , Zhou J. ^# (2023) Enzymatic hydrolysis on L-azetidine-2-carboxylate ring opening. Catal Sci & Technol , 13: 3953-3962. 【Link】

78. Ohashi, M., D. Tan, J. Lu, C. S. Jamieson, D. Kanayama, J. Zhou^#, K. N. Houk^# and Y. Tang^# (2023) Enzymatic cis-decalin formation in natural product biosynthesis. J Am Chem Soc, 145(6): 3301-3305.【Link】

71.Lee, Y., X. Hou, R. Chen, J. Feng, X. Liu, M. W. Ruszczycky, J. Gao^#, B. Wang^#, J. Zhou^# and H. Liu^#(2022) Radical S-Adenosyl methionine enzyme BlsE catalyzes a radical-mediated 1,2-diol dehydration during the biosynthesis of Blasticidin S. J Am Chem Soc, 144(10): 4478-4486.【Link】

77.Xu, X.^#, L. Yang, X. Zhang, X. Xing, J. Zhou^# (2023) Characterization and structural basis of D-cysteine desulfhydrase from Pectobacterium atrosepticum. Tetrahedron, 130:133174.【Link】

76.Wu P., Y. Gu, L. Liao, Y. Wu, J. Jin, Z. Wang, J. Zhou, S. Shaik^#, B. Wang^# (2022) Coordination Switch Drives Selective C−S Bond Formation by the Non-heme Sulfoxide Synthases. Angew Chem Int Edit, 61(50): e202214235.【Link】

75.Wang L., X. Zang, J. Zhou (2022) Synthetic biology: A powerful booster for future agriculture. Advanced Agarochem,1(1): 7-11.【Link】

70.Jin, J., J. Zhou (2022) The mystery of Z-genome biosynthesis has been elucidated. Syn Bio J, 3(1): 1-5.【Link】

67.Cheng, Q., Y. Cheung, C. Liu, Q. Xiao, B. Sun, J. Zhou, E. W. C. Chan, R. Zhang and S. Chen (2021) Structural and mechanistic basis of the high catalytic activity of monooxygenase Tet(X4) on tigecycline. BMC Biol, 19(1): 262.【Link】

1. Zhou, J., H. Chen (2000) A facile DNA shuffling protocol. Prog Biochem Biophys, 27(6): 655-657.【Link】

6.Xiao, J., H. Xia, K. Yoshino-Koh, J. Zhou and Z. Xu (2007) Structural characterization of the ATPase reaction cycle of endosomal AAA protein Vps4. J Mol Biol, 374(3): 655-670.【Link】

7.Xiao, J., H. Xia, J. Zhou, I. F. Azmi, B. A. Davies, D. J. Katzmann and Z. Xu (2008) Structural basis of Vta1 function in the multivesicular body sorting pathway. Dev Cell, 14(1): 37-49.【Link】

8.Lai, L., Z. Xu, J. Zhou, K. D. Lee and G. L. Amidon (2008) Molecular basis of prodrug activation by human valacyclovirase, an α-amino acid ester hydrolase. J Biol Chem, 283(14): 9318-9327.【Link】

9.Han, C., T. Hu, D. Wu, S. Qu, J. Zhou, J. Ding, X. Shen, D. Qu and H. Jiang (2009) X-ray crystallographic and enzymatic analyses of shikimate dehydrogenase from Staphylococcus epidermidis. FEBS J, 276(4): 1125-1139.【Link】

10.Zheng, C., H. Liu, J. Zhou and B. Zhang (2010) EF-hand domains of MCFD2 mediate interactions with both LMAN1 and coagulation factor V or VIII. Blood, 115(5): 1081-1087.【Link】

11.Zheng, C., H. Liu, S. Yuan, J. Zhou and B. Zhang (2010) Molecular basis of LMAN1 in coordinating LMAN1-MCFD2 cargo receptor formation and ER-to-Golgi transport of FV/FVIII. Blood, 116(25): 5698-5706.【Link】

12.Zhu, C., X. Li, W. Li, Z. Shi, J. Zhou, R. Wang (2010) Expression, purification and activity analysis of three Bcl-2 family proteins. J Biomedl Eng, 27(4): 834-841.【Link】

13.Ma, H., J. He, X. Liu, J. Gan, G. Jin and J. Zhou (2010) Surface initiated polymerization from substrates of low initiator density and its applications in biosensors. ACS Appl Mater Interfaces, 2(11): 3223-3230.【Link】

14.Ren, A., Z. Xia, W. Yu and J. Zhou (2010) Expression, crystallization and preliminary X-ray analysis of an anomeric inverting agarase from Pseudoalteromonas sp. CY24. Acta Crystallogr Sect F Struct Biol Cryst Commun, 66(12): 1635-1639.【Link】

15.Tao, W., Z. Gao, Z. Gao, J. Zhou, Z. Huang, Y. Dong and S. Yu (2011) The 1.6Å resolution structure of activated D138L mutant of catabolite gene activator protein with two cAMP bound in each monomer. Int J Biol Macromol, 48(3): 459-465.【Link】

16.Zhou, B., X. Li, Y. Li, Y. Xu, Z. Zhang, M. Zhou, X. Zhang, Z. Liu, J. Zhou, C. Cao, B. Yu and R. Wang (2011) Discovery and development of thiazolo [3,2-a] pyrimidinone derivatives as general inhibitors of Bcl-2 family proteins. ChemMedChem, 6(5): 904-921.【Link】

20.Kong X., H. Yu, J. Zhou, J. Xu (2013) Structure basis of EHs and development of novel EHs as biocatalyst. Chin J Biomed Eng, 11(01): 77-86.【Link】

17.Cai, C., L. Wu, C. Li, P. He, J. Zhou and J. Li (2011) Purification, crystallization and preliminary X-ray analysis of phycocyanin and phycoerythrin from Porphyra yezoensis Ueda. Acta Crystallogr Sect F Struct Biol Cryst Commun, 67(5): 579-583.【Link】

23.Yang, F., X. Wang, Z. Zhang, J. Pu, Y. Fan, J. Zhou, C. C. Query and Y. Xu (2013) Splicing proofreading at 5' splice sites by ATPase Prp28p. Nucleic Acids Res, 41(8): 4660-4670.【Link】

22.Sun, Y., H. Song, J. Li, Y. Li, M. Jiang, J. Zhou^# and Z. Guo^# (2013) Structural basis of the induced-fit mechanism of 1,4-dihydroxy-2-naphthoyl coenzyme A synthase from the crotonase fold superfamily. PLoS One, 8(4): e63095.【Link】

28.Dou, S., X. Kong, B. Ma, Q. Chen, J. Zhang, J. Zhou^# and J. Xu^# (2014) Crystal structures of Pseudomonas putida esterase reveal the functional role of residues 187 and 287 in substrate binding and chiral recognition. Biochem Biophys Res Commun, 446(4): 1145-1150.【Link】

29.Sun, Y., S. Yin, Y. Feng, J. Li, J. Zhou, C. Liu, G. Zhu and Z. Guo (2014) Molecular basis of the general base catalysis of an α/β-hydrolase catalytic triad. J Biol Chem, 289(22): 15867-15879.【Link】

34.Chen, J., X. Luo, Q. Chen, J. Pan^#, J. Zhou and J. Xu^# (2015) Marked enhancement of Acinetobacter sp. organophosphorus hydrolase activity by a single residue substitution Ile211Ala. Bioresour and Bioprocess, 2(1): 39.【Link】

35.Kong, X., H. Yu, S. Yang, J. Zhou, B. Zeng and J. Xu (2015) Chemoenzymatic synthesis of (R)- and (S)-propranolol using an engineered epoxide hydrolase with a high turnover number. Journal of Molecular Catalysis B: Enzymatic, 122: 275-281.【Link】

36.Luan, Z., F. Li, S. Dou, Q. Chen, X. Kong, J. Zhou, H. Yu^# and J. Xu^# (2015) Substrate channel evolution of an esterase for the synthesis of cilastatin. Catal Sci & Technol, 5(5): 2622-2629.【Link】

38.Sun, Z., R. Lonsdale, A. Ilie, G. Li, J. Zhou and M. T. Reetz (2016) Catalytic asymmetric reduction of difficult-to-reduce ketones: triple-code saturation mutagenesis of an alcohol dehydrogenase. ACS Catal, 6(3): 1598-1605.【Link】

39.Zhou, M., L. Xie, Z. Yang, J. Zhou^# and J. Xie^# (2017) Lysine succinylation of Mycobacterium tuberculosis isocitrate lyase (ICL) fine-tunes the microbial resistance to antibiotics. J Biomol Struct Dyn, 35(5): 1030-1041.【Link】

40.Zhu, H., G. Xu, K. Zhang, X. Kong, R. Han, J. Zhou^# and Y. Ni^# (2016) Crystal structure of tyrosine decarboxylase and identification of key residues involved in conformational swing and substrate binding. Sci Rep, 6: 27779.【Link】

43.Li, M., Z. Zhang, X. Kong, H. Yu, J. Zhou^# and J. Xu^# (2017) Engineering streptomyces coelicolor carbonyl reductase for efficient atorvastatin precursor synthesis. Appl Environ Microbiol, 83(12): e00603-17.【Link】

57.Chen, C., L. Su^#, L. Wu, J. Zhou and J. Wu^# (2020) Enhanced the catalytic efficiency and thermostability of maltooligosyltrehalose synthase from Arthrobacter ramosus by directed evolution. Biochem Eng J, 162: 107724.【Link】

63.Xiang, M. Wang, Wu, Z. Lu, J. Tang, J. Zhou, W. Huang^#, and G. Zhang^# (2021) Structural insights into xylanase mutant 254RL1 for improved activity and lower pH optimum, Enzyme Microb Technol, 147: 109786.【Link】

74.Zhang, J., X. Hou, Z. Chen, Y. Ko, M. W. Ruszczycky, Y. Chen, J. Zhou^# and H. Liu^# (2022) Dioxane bridge formation during the biosynthesis of spectinomycin involves a twitch radical SAM dehydrogenase that may have evolved from an epimerase. J Am Chem Soc, 144(22): 9910-9919.【Link】

2.Wang, Y.^*, J. Zhou^*, Y. Wang, J. Bao and H. Chen (2001) Properties of hybrid enzymes between Synechococcus large subunits and higher plant small subunits of ribulose-1,5-bisphosphate carboxylase/oxygenase in Escherichia coli. Arch Biochem Biophys, 396(1): 35-42.【Link】

4.Zhou, J., Z. Xu (2005) The structural view of bacterial translocation-specific chaperone SecB: implications for function. Mol Microbiol, 58(2): 349-357.【Link】

18.Diao, L., Q. Dong, Z. Xu, S. Yang, J. Zhou^# and R. Freudl^# (2012) Functional implementation of the posttranslational SecB-SecA protein-targeting pathway in Bacillus subtilis. Appl Environ Microb, 78(3): 651-659.【Link】

19.Sun, Y., H. Song, J. Li, M. Jiang, Y. Li, J. Zhou^# and Z. Guo^# (2012) Active site binding and catalytic role of bicarbonate in 1,4-dihydroxy-2-naphthoyl coenzyme A synthases from vitamin K biosynthetic pathways. Biochemistry, 51(22): 4580-4589.【Link】

21.Zhang, Z., X. Zhang, Z. Zhou, H. Hu, M. Liu, B. Zhou^# and J. Zhou^# (2013) Solution structure of the Magnaporthe oryzae avirulence protein AvrPiz-t. J Biomol Nmr, 55(2): 219-223.【Link】

24.Ma, J., L. Wu, F. Guo, J. Gu, X. Tang, L. Jiang, J. Liu, J. Zhou^# and H. Yu^# (2013) Enhanced enantioselectivity of a carboxyl esterase from Rhodobacter sphaeroides by directed evolution. Appl Microbiol Biot, 97(11): 4897-4906.【Link】

26.Zhang, Z., F. Yang, J. Zhang, Q. Tang, J. Li, J. Gu, J. Zhou^# and Y. Xu^# (2013) Crystal structure of Prp5p reveals interdomain interactions that impact spliceosome assembly. Cell Rep, 5(5): 1269-1278.【Link】

25.Xu, Z., S. Li, J. Li, Y. Li, X. Feng, R. Wang, H. Xu^# and J. Zhou^# (2013) The structural basis of erwinia rhapontici isomaltulose synthase. Plos One, 8(9): e74788.【Link】

27.Li, J., C. Wang, Z. Zhang, Y. Cheng^# and J. Zhou^# (2014) The structural basis of an NADP(+)-independent dithiol oxidase in FK228 biosynthesis. Sci Rep-Uk, 4: 4145.【Link】

30.Luo, X., X. Kong, J. Zhao, Q. Chen, J. Zhou^# and J. Xu^# (2014) Switching a newly discovered lactonase into an efficient and thermostable phosphotriesterase by simple double mutations His250Ile/Ile263Trp. Biotechnol Bioeng, 111(10): 1920-1930.【Link】

31.Kong, X., Q. Ma, J. Zhou^#, B. Zeng^# and J. Xu^# (2014) A smart library of epoxide hydrolase variants and the top hits for synthesis of (S)-β-blocker precursors. Angew Chem Int Ed Engl, 53(26): 6641-6644.【Link】

32.Kong, X., S. Yuan, L. Li, S. Chen, J. Xu^# and J. Zhou^# (2014) Engineering of an epoxide hydrolase for efficient bioresolution of bulky pharmaco substrates. Proc Natl Acad Sci U S A, 111(44): 15717-15722.【Link】

33.Sun, Z., R. Lonsdale, X. Kong, J. Xu, J. Zhou^# and M. T. Reetz^# (2015) Reshaping an enzyme binding pocket for enhanced and inverted stereoselectivity: use of smallest amino acid alphabets in directed evolution.Angew Chem Int Edit, 54(42): 12410-12415.【Link】

37.Sun, Z., R. Lonsdale, L. Wu, G. Li, A. Li, J. Wang, J. Zhou^# and M. T. Reetz^# (2016) Structure-guided triple-code saturation mutagenesis: efficient tuning of the stereoselectivity of an epoxide hydrolase. Acs Catal, 6(3): 1590-1597.【Link】

42.Zhang, J., N. Liu, R. A. Cacho, Z. Gong, Z. Liu, W. Qin, C. Tang, Y. Tang^# and J. Zhou^# (2016) Structural basis of nonribosomal peptide macrocyclization in fungi. Nat Chem Biol, 12(12): 1001-1003.【Link】

44.Yuan, H., J. Zhang, Y. Cai, S. Wu, K. Yang, H. C. S. Chan, W. Huang, W. B. Jin, Y. Li, Y. Yin, Y. Igarashi, S. Yuan^#, J. Zhou^# and G. Tang^# (2017) GyrI-like proteins catalyze cyclopropanoid hydrolysis to confer cellular protection. Nat Commun, 8(1): 1485.【Link】

45.Sun, Z., L. Wu, M. Bocola, H. C. S. Chan, R. Lonsdale, X. D. Kong, S. Yuan^#, J. Zhou^# and M. T. Reetz^# (2018) Structural and computational insight into the catalytic mechanism of limonene epoxide hydrolase mutants in stereoselective transformations. J Am Chem Soc, 140(1): 310-318.【Link】

46.Li, Y., W. Zhang, H. Zhang, W. Tian, L. Wu, S. Wang, M. Zheng, J. Zhang, C. Sun, Z. Deng, Y. Sun, X. Qu^# and J. Zhou^# (2018) Structural basis of a broadly selective acyltransferase from the polyketide synthase of splenocin. Angew Chem Int Ed Engl, 57(20): 5823-5827.【Link】

47.Yan, Y., Q. Liu, X. Zang, S. Yuan, U. Bat-Erdene, C. Nguyen, J. Gan, J. Zhou^#, S. E. Jacobsen^# and Y. Tang^# (2018) Resistance-gene-directed discovery of a natural-product herbicide with a new mode of action. Nature, 559(7714): 415-418.【Link】

48.Zhou, J., Y. Wang, G. Xu, L. Wu, R. Han, U. Schwaneberg, Y. Rao, Y. L. Zhao, J. Zhou^# and Y. Ni^# (2018) Structural insight into enantioselective inversion of an alcohol dehydrogenase reveals a "polar gate" in stereorecognition of diaryl ketones. J Am Chem Soc, 140(39): 12645-12654.【Link】

49.Xu, J., Y. Cen, W. Singh, J. Fan, L. Wu, X. Lin, J. Zhou^#, M. Huang^#, M. T. Reetz^# and Q. Wu^# (2019) Stereodivergent protein engineering of a lipase to access all possible stereoisomers of chiral esters with two stereocenters. J Am Chem Soc, 141(19): 7934-7945.【Link】

51.Cai, Y., Y. Hai, M. Ohashi, C. S. Jamieson, M. Garcia-Borras, K. N. Houk^#, J. Zhou^# and Y. Tang^# (2019) Structural basis for stereoselective dehydration and hydrogen-bonding catalysis by the SAM-dependent pericyclase LepI. Nat Chem, 11(9): 812-820.【Link】

52.Chen, T., J. Chen, Y. Tang, J. Zhou^#, Y. Guo^# and W. Chang^# (2020) Pathway from N-alkylglycine to alkylisonitrile catalyzed by Iron (II) and 2-oxoglutarate-dependent oxygenases. Angew Chem Int Ed Engl, 59(19): 7367-7371.【Link】

53.Li, A., C. G. Acevedo-Rocha, L. D'Amore, J. Chen, Y. Peng, M. Garcia-Borras, C. Gao, J. Zhu, H. Rickerby,S. Osuna^#, J. Zhou^# and M. T. Reetz^# (2020) Regio- and stereoselective steroid hydroxylation at C7 by cytochrome P450 monooxygenase mutants. Angew Chem Int Ed Engl, 59(30): 12499-12505.【Link】

54.Yang, X., L. Wu, A. Li, L. Ye^#, J. Zhou^# and H. Yu^# (2020) The engineering of decameric D-fructose-6-phosphate aldolase A by combinatorial modulation of inter- and intra-subunit interactions. Chem Commun (Camb), 56(55): 7561-7564.【Link】

58.Ohashi, M., C. S. Jamieson, Y. Cai, D. Tan, D. Kanayama, M. C. Tang, S. M. Anthony, J. V. Chari, J. S. Barber, E. Picazo, T. B. Kakule, S. Cao, N. K. Garg, J. Zhou^#, K. N. Houk^# and Y. Tang^# (2020) An enzymatic Alder-ene reaction. Nature, 586: 64-69.【Link】

59.Yan, Y., X. Zang, C. S. Jamieson, H. Lin, K. N. Houk, J. Zhou^# and Y. Tang^# (2020) Biosynthesis of the fungal glyceraldehyde-3-phosphate dehydrogenase inhibitor heptelidic acid and mechanism of self-resistance. Chem Sci, 11(35): 9554-9562.【Link】

60.Chen, T., J. Chen, Y. Tang, J. Zhou^#, Y. Guo^# and W. Chang^# (2021) Current understanding toward isonitrile group biosynthesis and mechanism. Chin J Chem, 39(2): 463-472.【Link】

61.Gao, D., C. S. Jamieson, G. Wang, Y. Yan, J. Zhou^#, K. N. Houk^#, and Y. Tang^# (2021) A polyketide cyclase that forms medium-ring lactones. J Am Chem Soc, 143: 80-84.【Link】

62.Liu, N., L. Wu, J. Feng, X. Sheng^#, J. Li, X. Chen, J. Li, W. Liu, J. Zhou^#, Q. Wu^#, and D. Zhu^# (2021) Crystal structures and catalytic mechanism of L-erythro-3,5-diaminohexanoate dehydrogenase and rational engineering for asymmetric synthesis of β-amino acids, Angew Chem Int Ed, 60: 10203-10.【Link】

64.Xie, L., X. Zang, W. Cheng, Z. Zhang, J. Zhou^#, M. Chen^# and Y. Tang^# (2021) Harzianic acid from Trichoderma afroharzianum is a natural product inhibitor of acetohydroxyacid synthase. J Am Chem Soc, 143(25): 9575-9584.【Link】

65.Li, S., P. D. Bury, F. Huang, J. Guo, G. Sun, A. Reva, C. Huang, X. Jian, Y. Li, J. Zhou, Z. Deng, F. J. Leeper^#, P. F. Leadlay^#, M. V. B. Dias^# and Y. Sun^# (2021) Mechanistic insights into dideoxygenation in gentamicin biosynthesis. Acs Catal, 11(19): 12274-12283.【Link】

66.Wen, W., Y. Zhang, Y. Zhang, Q. Yu, C. Jiang, M. Tang, J. Pu, L. Wu, Y. Zhao, T. Shi, J. Zhou ^# and G. Tang ^# (2021) Reductive inactivation of the hemiaminal pharmacophore for resistance against tetrahydroisoquinoline antibiotics. Nat Commun , 12(1): 7085. 【Link】

69.Chen, T., Z. Zheng, X. Zhang, J. Chen, L. Cha, Y. Tang, Y. Guo^#, J. Zhou^#, B. Wang^#, H. Liu^# and W. Chang^# (2022) Deciphering the reaction pathway of mononuclear iron enzyme-catalyzed N≡C triple bond formation in isocyanide lipopeptide and polyketide biosynthesis. Acs Catal, 12(4): 2270-2279.【Link】

3.Zhou, J., Z. Xu (2003). Structural determinants of SecB recognition by SecA in bacterial protein translocation. Nat Struct Biol, 10(11): 942-947.【Link】

5.Zhou, J.^*, C. Liu^*, S. H. Back, R. L. Clark, D. Peisach, Z. Xu^# and R. J. Kaufman^# (2006) The crystal structure of human IRE1 luminal domain reveals a conserved dimerization interface required for activation of the unfolded protein response. Proc Natl Acad Sci U S A, 103(39): 14343-14348.【Link】

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