Through collaborations with other labs at iSynBio, via quantitative data analysis and computational modeling study, we want to understand how the engineered bacteria strains eliminate mice tumors.

Investigating the mechanistic links between cancer-cell EMT and immune-infiltration in solid tumors

Through coculturing cancer cells and CAR-T cells in vitro, we want to understand how cancer cells hinder the infiltration of CAR-T cells into tumor spheroids.