Traditional paradigm of cell-surface interactions has been dominated by the study of proteins and lipids. The recent discovery of glycosylated RNAs (glycoRNAs) on the cell membranes surface represents a fundamental expansion of this landscape. These novel biomolecules, where classical N-glycans are conjugated to non-coding RNAs, challenge our understanding of the molecular language of cellular communication. We are investigating the precise roles that membrane-associated RNAs play in mediating cell-to-cell recognition, adhesion, and signaling.