Diagnostic Proteomic Methods

Views:825       Publish Time: 2019-06-21

Proteins in the circulatory system can provide important information about an individual’s health. For example, blood, plasma, and serum are the predominant samples used for diagnostic analyses in clinical practice. The development of mass spectrometry-based high-throughput, accurate diagnostic proteomics methods has great advantages for the purpose of finding biomarkers for diseases such as tumors, neurodegenerative diseases etc.. However, MS-based plasma proteomics is extremely challenging because of the high dynamic range of protein abundances. Therefore, in order to analyze large cohorts, there is a need to develop improved methods for high throughput and accurate serum proteomic profiling, which will allow for biomarker discovery and other improved diagnostic applications.