Activity-based Metaproteomics

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Activity-based metaproteomics is a new technology based on Activity-based protein profiling, and has been used to study the active proteins in a microbial community. Activity-based protein profiling allows for the screening of a certain type of protein with specific functions in a complex life system. The proteins identified in the screen can then be synthesized in vitro, producted in large quantities, purified, their enzyme activity characterized and optimized, In the final step, the proteins of interest can be used for industrial applications. For example, one application is using Activity-based protein profiling to screen out several α-galactosidase enzymes from the intestinal microflora. Our research group has successfully identified several α-galactosidase enzymes, which will then be used to convert type A blood into type O blood, which can be used for life-saving clinical and emergency blood transfusions.