盛宗海,博士,中国科学院深圳先进技术研究院研究员,博士生导师,广东省特支计划青年拔尖人才,深圳市高层次人才。研究领域:分子影像与分子探针。主持国自然科学基金4项,科技部重点专项2项。近五年以通讯作者在Nature Biomedical Engineering,Nature Communications等国际期刊发表论文30余篇,共他引10000余次,单篇最高他引600余次,6篇论文入选ESI高被引论文,13项专利实现产业化转移,X光激活探针用于放疗剂量定量成像进入临床研究,成果获广东省科学技术二等奖,深圳市自然科学二等奖。担任基金委重点项目函评专家和广东省科技奖会评专家。兼任中国生物医学工程学会纳米医学与工程分会副主任委员,中国生物物理学会分子影像专业委员会委员,广东省精准医学应用学会分子影像分会常委,广东省药学会核素药物专委会常委,国际期刊Research,Exploration,iRADIOLOGY,MedMat青年编委。

  1. Yuxia Liu#, Duyang Gao#, Yuanyuan He, Jing Ma, Suet Yen Chong, Xinyi Qi, Hui Jun Ting, Zichao Luo, Zhigao Yi, Jingyu Tang, Chao Chang, Jiongwei Wang, Zonghai Sheng*, Hairong Zheng*, Xiaogang Liu*, Single-point mutated lanmodulin as a high-performance MRI contrast agent for vascular and kidney imaging, Nature Communications, 2024, 15, 15, 9834 (IF: 14.74).

  2. Zhen Chen#, Linjian Huang#, Duyang Gao#, Zhouzhou Bao*, Dehong Hu, Wei Zheng, Jing Chen*, Jiuling Liao*, Hairong Zheng, Zonghai Sheng*, High Spatiotemporal Near‐Infrared II Fluorescence Lifetime Imaging for Quantitative Detection of Clinical Tumor Margins, Advanced Sciences, 2411272 (IF: 17.521).

  3. Bo Hou#, Luying Yi#, Dehong Hu, Zichao Luo, Duyang Gao, Chao Li, Bowen Xing, Jiong-Wei, Wang, Chuen Neng Lee, Rong Zhang, Zonghai Sheng*, Bin Zhou*, Xiaogang Liu*, A Swallowable X-ray Dosimeter for Real-time in vivo Radiotherapy Monitoring, Nature Biomedical Engineering, 2023, 7, 1242-1251 (IF: 29.234).

  4. Xinping Luo#, Dehong Hu#, Duyang Gao, Yuenan Wang, Xinhua Chen, Xin Liu, Hairong Zheng, Minjie Sun*, Zonghai Sheng*, Metabolizable near-infrared-II nanoprobes for dynamic imaging of deep-seated tumor-associated macrophages in pancreatic cancer, ACS Nano, 2021, 15, 10010 (IF: 18.027).

  5. Bing Guo, Zhe Feng, Dehong Hu, Shidang Xu, Eshu Middha, Yutong Pan, Chengbo Liu, Hairong Zheng, Jun Qian*, Zonghai Sheng*, Bin Liu*, Precise deciphering of brain vasculatures and microscopic tumors with dual NIR‐II fluorescence and photoacoustic imaging, Advanced Materials, 2019, 31, 1902504. (IF: 32.086).

  6. Zichao Luo#, Dehong Hu#, Duyang Gao, Zhigao Yi, Hairong Zheng, Zonghai Sheng*, Xiaogang Liu*, High‐specificity in vivo tumor imaging using bioorthogonal NIR-IIb nanoparticles, Advanced Materials, 2021, 33, 2102950. (IF: 32.086).

  7. Zihan Mei#, Duyang Gao#, Dehong Hu, Huichao Zhou, Teng Ma, Liang Huang, Xin Liu, Rongqin Zheng, Hairong Zheng, Ping Zhao*, Jianqiao Zhou*, Zonghai Sheng*, Activatable NIR-II photoacoustic imaging and photochemical synergistic therapy of MRSA infections using miniature Au/Ag nanorods, Biomaterials, 2020, 251, 120092. (IF: 15.304)

  8. Simin Liang#, Dehong Hu#, Guofeng Li, Duyang Gao, Fei Li, Hairong Zheng*, Min Pan*, Zonghai Sheng*, NIR-II fluorescence visualization of ultrasound-induced blood–brain barrier opening for enhanced photothermal therapy against glioblastoma using indocyanine green microbubbles, Science Bulletin, 2022, 67, 2316. (IF: 20.577)

  9. Si Zheng#, Duyang Gao#, Yayun Wu, Dehong Hu, Ziyue Li, Yuenan Wang, Hairong Zheng*, Yingjia Li*, Zonghai Sheng*, X-ray-activatable Au/Ag nanorods for radio-immuno oncotherapy sensitization and monitoring of the therapeutic response using NIR-II photoacoustic imaging, Advanced Science, 2023, 2206979. (IF: 17.521)

  10. Duyang Gao, Zichao Luo, Yang He, Lixiang Yang, Dehong Hu, Yongye Liang, Hairong Zheng*, Xiaogang Liu*, Zonghai Sheng*, Low-dose NIR-II preclinical bioimaging using liposome-encapsulated cyanine dyes, Small, 2023, 2206544. (IF: 15.153)

  11. Shichao Wang, Zonghai Sheng*, Zhenguo Yang, Dehong Hu, Xiaojing Long, Gang Feng, Yubin Liu, Zhen Yuan, Jingjing Zhang, Hairong Zheng, Xuanjun Zhang*, Activatable small‐molecule photoacoustic probes that cross the blood–brain barrier for visualization of copper (II) in mice with Alzheimer's disease, Angewandte Chemie International Edition, 2019, 58, 12415. (IF: 16.823)

  12. Zichao Luo, Yayun Wu, Yuenan Wang, Dehong Hu, Duyang Gao, Yongshuai Ge, Zonghai Sheng*, Xiaogang Liu*, Hairong Zheng*, Clinical radiation dose verification by topographic persistent luminescence dosimetry, Nano Today, 2023, 50, 101854. (IF: 18.962)

  1.国家自然科学基金委员会,重大研究计划培育项目,近红外二区荧光分子探针用于胰管恶性病变的动态可视化研究,2019.01至2021.12,60万元,结题,主持

  2.国家自然科学基金委员会,国家重点研发计划(内地-澳门合作),近红外二区光声探针用于成像引导脑胶质瘤精准手术的研究,2018.01至2020.12,80 万元,结题,主持

  3.国家自然科学基金委员会,面上项目,二区荧光探针标记工程菌可视化治疗脑胶质瘤的方法与机制研究,2024.01至2027.12,48万,结题,主持

  4.国家自然科学基金委员会,面上项目, 二级协同靶向吲哚菁绿纳米探针用于脑胶质瘤光学诊疗一体化研究,2016.01至2019.12,67.8 万,结题,主持

  5.国家自然科学基金委员会, 青年科学基金项目,叶酸受体靶向的石墨烯光声层析分子成像探针的研究,2014.01至2016.12,23 万,结题,主持

  6.国家自然科学基金委员会,重大研究计划集成项目,CAR-T体内命运及与胶质瘤酸性微环境时空相关性的可视化研究,2022.01至2025.12,350 万,在研,参与

  7.深圳市自然科学基金,基础研究重点项目,新型光声探针及其在AD早期诊断中的应用研究,2021.01至2023.12,200万,结题,主持

  8.国家自然科学基金委员会,重点研发计划,磁共振神经电活动探测与成像,2023.12至2026.12,700万,在研,主持

  9.深圳市医学科学院,前沿探索项目,可穿戴在体放疗剂量计的研制与应用,2024.01至2026.12,300万,在研,主持

  (1) 盛宗海,郑海荣,胡德红,高笃阳,刘新,一种用于脑部疾病诊断和治疗的微针系统及其制备方法,CN114948852A,20220830,发明

  (2) 盛宗海,郑海荣,胡德红,刘新,杀菌剂及其制备方法和应用,CN202011267146.4,2020-11-13,发明

  (3) 盛宗海,胡德红,郑海荣,刘新,一种二硬脂酰磷脂酰乙醇胺的制备方法,CN202011421108.X,20201210,发明

  (4) 郑海荣,盛宗海,耿晓瑞,高笃阳,胡德红,一种用于近红外二区荧光检测的吲哚菁绿脂质体及其制备方法和用途,CN201911272879.4,20191212,发明

  (5) 郑海荣,盛宗海,胡德红,刘新,一种诊疗一体化的凋亡小体及其制备方法,CN202110743610.0,20210630,发明

  (6) 郑海荣,盛宗海,胡德红,稀土核壳纳米材料及其制备方法,CN202110582514.2,2021527,发明

  (7) 郑海荣,盛宗海,胡德红,一种多模态微泡造影剂及其制备方法和应用,CN202110857642.3,2021728,发明

  (8) 蔡林涛,盛宗海,胡德红,一种包含吲哚青绿的多聚体白蛋白纳米球及其制备方法和应用,CN201410337773.9,2014716,发明