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共为您找到21个结果

9.218824 2025-05-06 18:08:03

Visiting Students
Nanzhu CHEN（陈南柱）
MS Biotechnology South China University of Technology
Biotechnology South 陈南柱 China University
系统管理员   2025-05-06 18:09:25

7.1180315 2025-04-27 10:57:34

JOIN US
Principle Investigators
IVacancies Available 1Professor of Plant Natural Products 2Professor of Microbial Natural Products 3Professor of In Vitro Biology 4Professor of Microbiome Engineering 5Professor of Metabolic Engineering 6Professor of Enzyme Engineering 7Professor of Bioinformatics and Retrobiosynthesis 8Professor of Custom-Made Microbes 9Professor of Metabolic Pathway and Whole-Cell Modeling 10Professor of Bioprocess Engineering and Commercialization 11Director of Analytical and High-Throughput Biochemistry All positions are open at assistant professor, associate professor, and full professor level IIJob Descriptions 1Professor of Plant Natural Products Job descriptions: aLead a team of scientists that will identify interesting and important plant natural products and use the latest advances in bioinformatics, high throughput biology, and synthetic biology to identify and characterize the enzymes in those pathways bWork with microbial synthetic biologists to refactor those pathways into industrial microorganisms for the production of the target molecules Job requirements: aHave a PhD and post-doctoral work in plant biology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in plant natural products bPriority to a resume that qualifies him/her for a Thousand Talents Plan award 2Professor of Microbial Natural Products Job descriptions: aLead a team of scientists that will identify interesting and important microbially-produced natural products and use the latest advances in bioinformatics, high throughput biology, and synthetic biology to identify and characterize the enzymes in those pathways bWork with microbial synthetic biologists to refactor those pathways into industrial microorganisms for the production of the target molecules Job requirements: aHave a PhD and post-doctoral work in microbiology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in microbial natural products bPriority to a resume that qualifies him/her for a Thousand Talents Plan award 3Professor of In Vitro Biology Job descriptions: aLead a team of scientists that will develop in vitro transcription-translation-reaction systems for reconstituting natural and unnatural biosynthetic pathways, both for scientific exploration and eventually for production of target molecules bWork with CSB teams that are focused on discovering new biosynthetic pathways in plants and microorganisms and with microbial synthetic biologists who are refactoring pathways into industrial microorganisms Job requirements: aHave a PhD and post-doctoral work in biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in in vitro biology bPriority to a resume that qualifies him/her for a Thousand Talents Plan award 4Professor of Microbiome Engineering Job descriptions: aLead a team of scientists that will identify key natural (or unnatural) products to deliver to the host (plant, animal, human), identify appropriate members of microbial communities to engineer, develop tools to engineer the microbiome constituent(s) and engineer it with pathways that produce the desired product bWork with CSB research groups that focus on plant and/or microbial natural products to refactor those pathways into the target microbiome constituent for the production of the target molecules cCollaborate with experts in human, animal or plant biology outside the CSB to examine the impact of the engineered microbiome on the health of the higher order system Job requirements: aHave extensive experience working with, studying and engineering microbiome constituents, particularly microorganisms that do not have good transformation systems bHave a PhD and post-doctoral work in microbiology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in microbial natural products cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 5Professor of Metabolic Engineering Job descriptions: aLead a team of scientists that will develop efficient metabolic pathways to transform renewable sources of energy and carbon (including sunlight and gaseous feedstocks) into valuable products In particular, the CSB is interested in developing highly efficient metabolic pathways to convert waste gas streams into valuable products bWork with the microbial engineering teams, the plant and microbial natural products teams, the microbiome engineering team and the custom-made microbe team to develop highly efficient metabolic pathways to a variety of candidate products Job requirements: aHave a strong background in metabolic pathway design and engineering in microorganisms bHave a PhD and post-doctoral work in microbiology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in metabolic engineering cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 6Professor of Enzyme Engineering Job descriptions: aLead a team of scientists that will develop new enzymes for chemical reactions for which enzymes do not exist or for reaction conditions that existing enzymes cannot tolerate bWork extensively with microbial and metabolic engineering teams as well as the in vitro biology and custom-made microbe teams to develop enzymes for new metabolic pathways, for new microbial chassis, and in vitro catalysis Job requirements: aHave a strong background in computational enzyme design and/or enzyme evolution and demonstrated experience in engineering enzymes for practical application bHave a PhD and post-doctoral work in biochemistry, bioengineering, chemistry, chemical engineering, or equivalent fields and demonstrated expertise (through publications and patents) in enzyme engineering cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 7Professor of Bioinformatics and Retrobiosynthesis Job descriptions: aLead a team of scientists that will develop computation methods and software that will allow CSB teams to elucidate natural biosynthetic pathways, construct new biochemical pathways, and aid in the design and construction of custom-made microbes bWork extensively with all of the research teams of the CSB Job requirements: aHave extensive experience in bioinformatics of microbial and plant secondary metabolic pathways and biochemical informatics as well as in software design bHave a PhD and post-doctoral work in biochemistry, bioengineering, chemistry, chemical engineering, or equivalent fields and demonstrated expertise (through publications and patents) in enzyme engineering cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 8Professor of Custom-Made Microbes Job descriptions: aLead a team of scientists that will design and construct custom-made microbes for chemical synthesis, including cells to be used in bioreactors and cells to be constituents of microbiomes bWork with the Metabolic Pathway and Whole Cell Modeling team, the Bioinformatics and Retrobiosynthesis team, and with the Genome-Write Center (also in the Institute for Synthetic Biology) to design and build custom-made microbes and with several other teams in the CSB to apply the custom-made microbes to produce valuable products Job requirements: aHave experience in chromosome engineering, cell wall-membrane engineering, and/or metabolic pathway refactoring bHave a PhD and post-doctoral work in bioengineering, microbiology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in designing cells cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 9Professor of Metabolic Pathway and Whole-Cell Modeling Job descriptions: aLead a team of scientists that will develop mathematically models and computer simulations of metabolic pathways and whole cells for the purpose of redesigning natural microbial chassis and for designing custom-made microbial chassis for production of valuable products bWork with all CSB research groups but particularly the Custom-Made Microbe group so that the two research groups can design, construct and optimize custom-made microbes Job requirements: aHave extensive experience in modeling and simulating gene expression, enzyme activities, metabolic pathways, and cell function as well as software design and implementation Have experience in developing methods for monitoring gene expression and metabolism and integrating those measurements into models bHave a PhD and post-doctoral work in microbiology, biochemistry or equivalent fields and demonstrated expertise (through publications and patents) in metabolic and whole-cell modeling cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 10Professor of Bioprocess Engineering and Commercialization Job descriptions: aLead a team of scientists/engineers that will scale-up processes developed by CSB research teams and prepare them for commercialization bWork with all CSB research groups to identify those processes most amenable to commercialization and then work with the originating scientific team to optimize the organism and process and help to license the technology or develop start-ups Job requirements: aHave extensive experience in engineering and optimizing microorganisms for industrial chemical production processes bHave a PhD in chemical engineering, bioengineering, or equivalent fields and demonstrated expertise (through publications and patents) in bioprocess engineering cPriority to a resume that qualifies him/her for a Thousand Talents Plan award 11Director of Analytical and High-Throughput Biochemistry Job descriptions: aLead a team of scientists that develop high throughput biochemical assays for various processes and to analyze engineered microorganisms using transcriptomics, proteomics, metabolomics and any number of other techniques bWork with all CSB research groups to speed sample analysis, increase information content, and analyze the resulting data Job requirements: aHave extensive experience in analytical chemistry as applied to biological systems bHave a PhD in analytical chemistry, or equivalent fields and demonstrated expertise (through publications and patents) in metabolomics, proteomics, automated analytics, etc A research program is optional IIIBenefits We offer internationally competitive salaries and benefits，ample start-up resources for equipment and personnel Qualified candidates for Thousand Talent Program, the Peacock Program or other talent programs will receive additional support from the central and municipal governments IVDocuments for Application 1Curriculum vitae, including full publication list 2Research interests and a statement of research plan 3Copies of three representative publications 4Three reference letters Application will be considered until the position is filled All documents will be treated confidentially VContact Information Email: keasling@siataccn
pathways Job metabolic CSB Have
系统管理员   2025-04-27 11:04:12

7.1170535 2025-04-27 10:51:39

BLOG
斯克里普斯研究所沈奔教授来访
2018年11月1日，美国斯克里普斯研究所分子医学系教授沈奔受邀来访合成生物化学研究中心，举办面向全院的学术报告。报告由合成生化中心执行主任罗小舟主持，报告题为“Challenges and Opportunities for Natural Products by Synthetic Biology”（《天然产物的合成生物所面临的挑战与机遇》），我院师生积极参与报告并与沈奔教授进行了深入交流。
报告 合成 沈奔 教授 来访
系统管理员   2025-04-27 10:55:26

7.1168165 2025-04-27 10:50:13

Papers
2019
Coming soon!
soon Coming
系统管理员   2025-04-27 10:50:44

7.1160398 2025-04-27 10:45:31

Papers
2018
Budin I, de Rond T, Chen Y, Chan LJG, Petzold CJ, Keasling JD*,Viscous control of cellular respiration by membrane lipid composition,Science, 362, 1186–1189 (2018) Yuzawa S, Zargar A, Pang B, Katz L, Keasling JD*,Commodity Chemicals From Engineered Modular Type I Polyketide Synthases,Methods in Enzymology,(2018) 608:393-415 Yuzawa S, Mirsiaghi M, Jocic R, Fujii T, Masson F, Benites VT, Baidoo EEK, Sundstrom E, Tanjore D, Pray TR, George A, Davis RW, Gladden JM, Simmons BA, Katz L, Keasling JD*,Short-chain ketone production by engineered polyketide synthases in Streptomyces albus,NATURE COMMUNICATIONS, (2018) 9:4569 Liu CL, Tian T, Alonso-Gutierrez J, Garabedian B, Wang S, Baidoo EEK, Benites V, Chen Y, Petzold CJ, Adams PD, Keasling JD*, Tan T, Lee TS,Renewable production of high density jet fuel precursor sesquiterpenes from Escherichia coli,Biotechnology for Biofuels, (2018) 11:285 Curran SC, Hagen A, Poust S, Chan LJG, Garabedian BM, de Rond T, Baluyot MJ, Vu JT, Lau AK, Yuzawa S, Petzold CJ, Katz L, Keasling JD*, Probing the Flexibility of an Iterative Modular Polyketide Synthase with Non-Native Substrates in Vitro,ACS Chemical Biology, 2018, 13, 2261−2268 Budin I, Keasling JD*, Synthetic Biology for Fundamental Biochemical Discovery, Biochemistry, 2018 (in press) Hanko EKR, Denby CM, Sànchez I Nogué V, Lin W4, Ramirez KJ, Singer CA, Beckham GT, Keasling JD*,Engineering β-oxidation in Yarrowia lipolytica for methyl ketone production,Metabolic Engineering, 48 (2018) 52–62 Jakociunas, T; Pedersen, LE; Lis, AV; Jensen, MK; Keasling, JD*,CasPER, a method for directed evolution in genomic contexts using mutagenesis and CRISPR/Cas9,Metabolic Engineering, 48 (2018) 288–296 Zargar, A; Barajas, JF; Lal, R; Keasling, JD*, Polyketide Synthases as a Platform for Chemical Product Design,AICHE JOURNAL, 2018,64,12:4201-4207
JD Keasling production Engineering Polyketide
系统管理员   2025-04-27 10:50:10

7.114935 2025-04-27 10:38:50

Research
Industrial microbial hosts
Develop a few industrial microbial hosts for production of isoprenoids,polyketide, nonribosomal peptides,and combinations thereof
hosts polyketide microbial isoprenoids production
系统管理员   2025-04-27 10:39:55

7.114188 2025-04-27 10:34:19

轮播图
Group Photo
Photo Group
系统管理员   2025-04-27 10:34:48

7.114012 2025-04-27 10:33:15

轮播图
In the lab
lab In
系统管理员   2025-04-27 10:34:15

6.4654117 2025-04-24 16:58:03

Administrative Assistants
Sijia CHEN（陈思佳）
MS Translation Chinese University of Hong Kong BS Translation Jinan University
Translation Chinese University Kong 陈思佳
系统管理员   2025-04-25 17:12:34

6.4654036 2025-04-24 16:58:00

Research Assistants
Rui DI （狄睿）
MSNutrition and Food Technology Chinese University of Hong Kong BSApplied Chemistry City University of Hong Kong
University Hong Kong Nutrition Food
系统管理员   2025-04-25 17:11:54