Yu, C#, H. Gan#, A. Serra-Cardona, L. Zhang, S. Gan, S. Sharma, E. Johansson, A. Chabes, R. M. Xu and Z. Zhang. "A mechanism for preventing asymmetric histone segregation onto replicating DNA strands". Science 361, 1386-1389 (2018). (Highlighted in Science and F1000)
Li, S., Z. Xu, J. Xu, L. Zuo, C. Yu, P. Zheng,H. Gan, X. Wang, L. Li and S. Sharma. "Rtt105 functions as a chaperone for replication protein A to preserve genome stability."The EMBO journal: e99154 (2018).
H. Gan#, A. Serra-Cardona#, X. Hua, H. Zhou, K. Labib, C. Yu and Z. Zhang. The Mcm2-Ctf4-Polα Axis Facilitates Parental Histone H3-H4 Transfer to Lagging Strands. Mol Cell 72(1): 140-151 e143 (2018).
Fang, D#, H. Gan#, L. Cheng, J. H. Lee, H. Zhou, J. N. Sarkaria, D. J. Daniels and Z. Zhang. H3.3K27M mutant proteins reprogram epigenome by sequestering the PRC2 complex to poised enhancers. ELife, 7 (2018).
H. Gan#, C. Yu#, S. Devbhandari, S. Sharma, J. Han, A. Chabes, D. Remus and Z. Zhang*,Checkpoint kinase Rad53 couples leading and lagging strand DNA synthesis under replication stress.Mol Cell68, 446-455 e443 (2017). (Highlighted in CellCycle)
Zhang, H#,H. Gan#, Z. Wang#, J. H. Lee, H. Zhou, T. Ordog, M. S. Wold, M. Ljungman and Z. Zhang*.RPA Interacts with HIRA and Regulates H3.3 Deposition at Gene Regulatory Elements in Mammalian Cells.Mol Cell, 65(2):272-284 (2017). (Highlighted in F1000)
Fang, D#,H. Gan#, J. H. Lee#, J. Han#, Z. Wang#, S. M. Riester, L. Jin, J. Chen, H.Zhou, J. Wang, H. Zhang, N. Yang, E. W. Bradley, T. H. Ho, B. P. Rubin, J. A. Bridge, S. N. Thibodeau, T. Ordog, Y. Chen, A. J. van Wijnen, A. M. Oliveira, R. M. Xu, J. J.Westendorf and Z. Zhang*,The histone H3.3K36M mutation reprograms the epigenome of chondroblastomas.Science352, 1344-1348 (2016). (Highlighted inF1000)
C. Yu#,H. Gan# and Z. Zhang*.Both DNA Polymerases delta and Contact Active and Stalled Replication Forks differently.Mol Cell Biol,37(21) (2017).
Feng, J#,H. Gan#, M. L. Eaton, H. Zhou, S. Li, J. A. Belsky, D. M. MacAlpine, Z. Zhang* and Q. Li*,Noncoding Transcription Is a Driving Force for Nucleosome Instability in spt16 Mutant Cells.Mol Cell Biol36, 1856-1867 (2016).
C. Yu#,H. Gan#, J. Han, Z. X. Zhou, S. Jia, A. Chabes, G. Farrugia, T. Ordog, Z. Zhang*.Strand-Specific Analysis Shows Protein Binding at Replication Forks and PCNA Unloading from Lagging Strands when Forks Stall.Mol Cell, 56, 551-563 (2014). (Highlighted in Molecular Cell and F1000)
H. Gan#, L. Wen#, S. Liao#, X. Lin, T. Ma, J. Liu, C. X. Song, M. Wang, C. He*, C. Han*, F. Tang*.Dynamics of 5-hydroxymethylcytosine during mouse spermatogenesis.Nat Commun4, 1995 (2013).
H. Gan#, T. Cai#, X. Lin, Y. Wu, X. Wang, F. Yang*, C. Han*.Integrative Proteomic and Transcriptomic Analyses Reveal Multiple Post-transcriptional Regulatory Mechanisms of Mouse Spermatogenesis.Mol Cell Proteomics, 12, 1144-1157 (2013).
H. Gan, X. Lin, Z. Zhang, W. Zhang, S. Liao, L. Wang, C. Han*.piRNA profiling during specific stages of mouse spermatogenesis.RNA, 17, 1191-1203 (2011).
Co-author
Hashizume, R., N. Andor, Y. Ihara, R. Lerner,H. Gan, X. Chen, D. Fang, X. Huang, M. W. Tom and V. Ngo. "Pharmacologic inhibition of histone demethylation as a therapy for pediatric brainstem glioma."Nature medicine20(12): 1394 (2014).
Chen, X., M. Zhang,H. Gan, H. Wang, J.-H. Lee, D. Fang, G. J. Kitange, L. He, Z. Hu and I. F. Parney. "A novel enhancer regulates MGMT expression and promotes temozolomide resistance in glioblastoma."Nature communications9(1): 2949 (2018).
Gao, Y.,H. Gan, Z. Lou and Z. Zhang. "Asf1a resolves bivalent chromatin domains for the induction of lineage-specific genes during mouse embryonic stem cell differentiation."PNAS115(27): E6162-E6171. (2018).
Li, S., Z. Xu, J. Xu, L. Zuo, C. Yu, P. Zheng, H. Gan, X. Wang, L. Li and S. Sharma. "Rtt105 functions as a chaperone for replication protein A to preserve genome stability." The EMBO journal: e99154 (2018).
Wu, R., Z. Wang, H. Zhang,H. Ganand Z. Zhang. "H3K9me3 demethylase Kdm4d facilitates the formation of pre-initiative complex and regulates DNA replication."Nucleic acids research45(1): 169-180. (2016).
Chan, K. M., J. Han, D. Fang,H. Ganand Z. Zhang. "A lesson learned from the H3. 3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?"Cell cycle12(16): 2546-2552 (2013).
Fang, D., H.Gan, H. Wang, H. Zhou and Z. Zhang."Probe the function of histone lysine 36 methylation using histone H3 lysine 36 to methionine mutant transgene in mammalian cells."Cell Cycle16(19): 1781-1789 (2017).
Hou, X., W. Zhang, Z. Xiao,H. Gan, X. Lin, S. Liao and C. Han. "Mining and characterization of ubiquitin E3 ligases expressed in the mouse testis."BMC genomics13(1): 495. (2012).
Yang, Y., Y. Feng, X. Feng, S. Liao, X. Wang,H. Gan, L. Wang, X. Lin and C. Han. "BMP4 cooperates with retinoic acid to induce the expression of differentiation markers in cultured mouse spermatogonia."Stem cells international.(2016).
Yang, Y., M. Leonand andH. Gan. "Viral and Nonviral Cancer Gene Therapy. THE WORLD SCIENTIFIC ENCYCLOPEDIA OF NANOMEDICINE AND BIOENGINEERING I: Volume 3: Nanotechnology in Gene Delivery",World Scientific:1-52. (2017).
Yu, C.,H. Ganand Z. Zhang. "Strand-Specific Analysis of DNA Synthesis and Proteins Association with DNA Replication Forks in Budding Yeast.Genome Instability, Springer: 227-238. (2018).
L Cheng, X Zhang, Y Wang,H Gan, X Xu, X Lv, X Hua, J Que, T Ordog. "Chromatin Assembly Factor 1 (CAF-1) facilitates the establishment of facultative heterochromatin during pluripotency exit."Nucleic acids research47 (21), 11114-11131. (2019)
JS Lee, Y Mo,H Gan, RJ Burgess, DJ Baker, JM van Deursen, Z Zhang. "Pak2 kinase promotes cellular senescence and organismal aging."Proceedings of the National Academy of Sciences116 (27), 13311-13319. (2019)
SW Yang, L Li, JP Connelly, SN Porter, K Kodali,H Gan, JM Park . "A cancer-specific ubiquitin ligase drives mRNA alternative polyadenylation by ubiquitinating the mRNA 3′ end processing complex."Molecular Cell77 (6), 1206-1221. e7. （2020）
Chan, K. M., J. Han, D. Fang,H. Ganand Z. Zhang. "A lesson learned from the H3. 3K27M mutation found in pediatric glioma: a new approach to the study of the function of histone modifications in vivo?"Cell cycle12(16): 2546-2552. (2013)