Chromatin states encode epigenetic information and must be stably transmitted to daughter cells to maintain gene expression and cell identity. However, the molecular mechanism of how the parental histone (the epigenetic information carrier) transferred to replicating DNA and how the marks on parental H3-H4 are copied to new (H3-H4)2 tetramers is largely unknown, which hinders our understanding of transmission of epigenetic information into daughter cells. We will study molecular the mechanism epigenetic inheritance in both yeast and mammalian cells, and the consequence of the epigenetic inheritance regulation.
