<center>人工合成多细胞斑图 </center> <center> Synthetic pattern formation</center>_

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Synthetic pattern formation

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Pattern formation refers to the generation of regular and complex spatial structures. Patterns are ubiquitous in the biological world and play essential roles in the development of organisms and ecosystems. How biosystems develop patterns autonomously is one of the fundamental questions in life science, and understanding the principle of pattern formation provides the foundation for engineering living systems with desired spatial structures.

Because of the extreme complexity and myriads of physiological/biochemical factors involved in pattern formation, it is often difficult to perturb or control a single factor in natural systems. Therefore, there is a great limitation to study pattern formation by conventional methods. Reconstructing biological patterns with synthetic biology allows us to simplify and control the systems, providing a new tool and research paradigm for studying pattern formation, which is one of the classical fields in synthetic biology. The design and construction of biosystems with spatial patterns also provides the possibility of synthetic biomaterials, tissues, and organs with controllable spatial structures.

The aim of this project is to elucidate the design principle of pattern formation. In this project, we will develop mathematical models to systematically investigate the system topologies that allow pattern formation during the range expansion of bacteria. Based on the quantitative predictions of modeling, we will design gene circuits and engineer synthetic bacterial strains. 

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