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Jiandong Huang

Professor

Jiandong Huang is a Professor in Shenzhen Institute of Advanced Technology (SIAT), Chinese Academy of Sciences,Prof. Huang earned his BS degree from Fudan University, Shanghai in 1988 and went to the US through the CUSBEA program to pursue his PhD study in transcriptional regulation during fruit fly embryonic pattern formation. He earned his PhD degree from the University of California, Los Angeles in 1994. Thereafter, Prof. Huang received his postdoctoral training in mouse genetics at National Cancer Institute, NIH in the USA from 1994-1998. During this period, Prof. Huang was the first to report that the two major intracellular transportation systems of mammalian cells, the microtubule- and actin-filament-based system directly interact with each other through their motor proteins, kinesin and myosin. He established his own laboratory at the University of Hong Kong in October 1998. Prof. Huang is now a professor in the School of Biomedical Sciences, the University of Hong Kong. Prof. Huang focused his research work on the studies of a highly efficient DNA engineering technology, recombineering. He has provided experimental evidence revealing the mechanism of recombineering and improved its efficiency in both E. coli and mammalian cells. He has applied this technique to genomic studies and developed more efficient methods in DNA and chromosome engineering. Since 2008, he began to pursue synthetic biology studies focus on vaccine development and cancer therapy. 黄博士于1988年在复旦大学获得学士学位，随后加入吉林大学进行研究生学习。他之后通过中美生化联合考试项目（CUSBEA）进入美国加州大学洛杉矶分校进行果蝇胚胎转录和生物图形形成的研究，并在1994年获得理学博士（PhD）学位。从1994到1998年，黄博士在美国国家健康研究院（NIH），国立癌症研究所（NCI）接受了小鼠遗传学博士后的训练。在这期间，黄博士在世界上首先发现并报告了哺乳细胞二个主要细胞内运输系统间直接相互作用的方式，即这两个系统是通过它们的马达蛋白质，kinesin和肌球蛋白直接联系的。1998年10月，黄博士在香港大学建立了他己的实验室。黄博士现在是香港大学生物医学学院的教授。过去几年间，黄博士的工作集中于研究一项可以高效改造脱氧核糖核酸的工程技术，DNA重组工程学（recombineering）。他提供了解释高效DNA重组机理的实验证据，提高了DNA重组工程学的在大肠杆菌和哺乳细胞的效率，并将这项技术用于基因组学的研究。他从2008年开始了合成生物学的研究，主要致力于编码细胞合成人工生物结构，并将人工编码的细胞用于生物医学的研究与开发，如疫苗开发、癌症治疗等。