Focusing on key scientific questions about microbial evolution and interacting mechanisms between microbes and corresponding environment, the Center for Quantitative Synthetic Biology (CQSB) has deployed two main research directions, which are theoretical foundation and enabling technology, and conducted extensive explorations in practical applications as well. In order to exploit the combination of quantitative technology and synthetic biology, the center has attracted multidisciplinary and complementary groups from synthetic biology, microbiology, physics, bioinformatics, microfluidics, and proteomics and so on, with more than ten outstanding young Principal Investigators and about 200 researchers.